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ProteomicsSMARCA2/4 degradation tails mediate recruitment of two different E3 ligases 
In this work, we characterise novel SMARCA2/4 degraders using a robust cell biology and structural workflow and reveal for the first time, the recruitment of two E3 ligase substrate receptors: FBXO22 and DCAF16 by the same degradation tail. Furthermore, we were able to chemically fine-tune this dual...
ORGANISM(S): Homo sapiens (Human) 
2026-05-16 | PXD065523 | Pride
E3 ligases  Smarca2/4 Protein degrader 
ProteomicsSMARCA2/4 degradation tails mediate recruitment of two different E3 ligases 
In this work, we characterise novel SMARCA2/4 degraders using a robust cell biology and structural workflow and reveal for the first time, the recruitment of two E3 ligase substrate receptors: FBXO22 and DCAF16 by the same degradation tail. Furthermore, we were able to chemically fine-tune this dual...
ORGANISM(S): Homo sapiens (Human) 
2026-05-16 | PXD065445 | Pride
Smarca2/4 E3 ligases  Protein degrader 
GenomicsChIP-seq of trascription factors after SMARCA2/4 degrader treatment
ChIP-seq of trascription factors after SMARCA2/4 degrader treatment
PRJNA1180564 | ENA
GenomicsNSD2 interacts with SMARCA2 and regulates expression of oncogenes CCND1 and PRL3 in t(4 14) multiple myeloma
NSD2 interacts with SMARCA2 and regulates expression of oncogenes CCND1 and PRL3 in t(4 14) multiple myeloma
PRJNA591170 | ENA
UnknownExpanding the clinicopathologic spectrum and genomic landscape of tumors with SMARCA2/4::CREM fusions.
Not available
S-EPMC12131337 | biostudies-literature
UnknownThe SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies.
Not available
S-EPMC4755107 | biostudies-literature
Genomicsbd573db7-8ea1-4307-9e52-c92b83a623d7 - samples
RNA-seq of SMARCA2/4 knock-down prostate cancer cell lines (LNCaP and 22Rv1, 15 samples altogether). Dataset contains BAM files from RNA-seq performed using Illumina HiSeq 2500.
EGAD00001005800 | EGA
GenomicsChIP-seq of trascription factors after SMARCA2/4 degrader treatment
Transcription factors (TFs) and transcriptional coregulators represent an emerging and exciting class of targets. By quantifying target gene modulation, gene regulatory networks (GRNs) delineate disease biology and evaluate pharmacological agents targeting these regulators. However, none of the exis...
ORGANISM(S): Homo sapiens 
2025-02-01 | GSE280803 | GEO
UnknownSelective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.
Not available
S-EPMC9649729 | biostudies-literature
UnknownDual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.
Not available
S-EPMC4832362 | biostudies-literature
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