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GenomicsActivation of the chromatin-remodeling factor Smarca4/Brg1 cooperates with Olig2 to establish oligodendrocyte identity and control CNS myelination [ChIP-seq]
We investigate the role of Brg1 and Olig2 during oligodendrocyte differentiation by combining gene conditional knockout and next generation sequencing technology. We generate genome-wide maps of RNA polymerase II (RPolII), Brg1 (Smarca4), Olig2 and histone modifications in primary rat oligodendrocyt...
ORGANISM(S): Rattus norvegicus 
2013-01-20 | E-GEOD-42447 | biostudies-arrayexpress
TranscriptomicsActivation of the chromatin-remodeling factor Smarca4/Brg1 cooperates with Olig2 to establish oligodendrocyte identity and control CNS myelination [RNA-seq]
Spinal cord mRNA profiles of 14-day-old control (Brg1c/+;Olig1-Cre) and Smarca4/Brg1 conditional knockout (Brg1c/c;Olig1-Cre) mice were generated by RNA-seq. Differential expressed genes are identified using Cuffdiff and validated with qPCR. Spinal cord mRNA profiles of 14-day old control and Brg1c/...
ORGANISM(S): Mus musculus 
2013-01-20 | E-GEOD-42443 | biostudies-arrayexpress
GenomicsChIP-Seq of human: SMARCA4 deficient /BRG1-inducible NSCLC isogenic cell lines
ChIP-Seq of human: SMARCA4 deficient /BRG1-inducible NSCLC isogenic cell lines
PRJNA648756 | ENA
ProteomicsRe-expression of SMARCA4/BRG1 in Small Cell Carcinoma of Ovary, Hypercalcemic Type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive form of ovarian cancer. SCCOHT tumors have inactivating mutations in SMARCA4 (BRG1), one of the two mutually exclusive ATPases of the SWI/SNF chromatin remodeling complex. To address the role that BRG1 loss plays...
ORGANISM(S): Homo sapiens (Human) 
2021-01-15 | PXD014134 | Pride
Ovarian carcinoma smarca4 
UnknownSWI/SNF chromatin remodeling subunit Smarca4/BRG1 is essential for female fertility†.
Not available
S-EPMC9930400 | biostudies-literature
TranscriptomicsMicroarray analysis of ATP-dependent chromatin remodeller BRG1/SMARCA4 mediated gene expression in primary human keratinocytes (PHEKs) after scratch wound assay.
siRNA mediated knockdown of BRG1/SMARCA4 in scratch wounded cell culture PHEKs, used to identify specific BRG1/SMARCA4 dependent gene expression programs which are initiated during immediate and early (1h and 24h) epithelial wounding. 3 human donors.
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-12452 | biostudies-arrayexpress
UnknownGermline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome.
Not available
S-EPMC2820190 | biostudies-literature
UnknownCellular expression of Smarca4 (Brg1)-regulated genes in zebrafish retinas.
Not available
S-EPMC3155967 | biostudies-literature
UnknownAutism-Associated Chromatin Regulator Brg1/SmarcA4 Is Required for Synapse Development and Myocyte Enhancer Factor 2-Mediated Synapse Remodeling.
Not available
S-EPMC4702607 | biostudies-literature
UnknownSMARCA4/BRG1 Is a Novel Prognostic Biomarker Predictive of Cisplatin-Based Chemotherapy Outcomes in Resected Non-Small Cell Lung Cancer.
Not available
S-EPMC4867280 | biostudies-literature
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