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UnknownTherapeutic errors involving diabetes medications reported to United States poison centers.

Background

To investigate the characteristics and trends of therapeutic errors that occur outside of healthcare facilities involving diabetes medications reported to US poison centers.

Methods

National Poison Data System data from 2000 to 2021 were retrospectively analyzed.

Results...

S-EPMC11412010 | biostudies-literature
UnknownTiming of Physical Activity, Apolipoprotein E ε4 Genotype, and Risk of Incident Mild Cognitive Impairment.

Objectives

To investigate the timing (mid- vs late life) of physical activity, apolipoprotein (APO)E ε4, and risk of incident mild cognitive impairment (MCI).

Design

Prospective cohort study.

Setting

Mayo Clinic Study of Aging (Olmsted County, MN).

Participants

Cognitive...
S-EPMC5173416 | biostudies-literature
UnknownTau, amyloid, and cascading network failure across the Alzheimer's disease spectrum.
Functionally related brain regions are selectively vulnerable to Alzheimer's disease pathophysiology. However, molecular markers of this pathophysiology (i.e., beta-amyloid and tau aggregates) have discrepant spatial and temporal patterns of progression within these selectively vulnerable brain regi...
S-EPMC5773067 | biostudies-literature
UnknownValidity and Reliability of Clinical and Patient-Reported Outcomes in Multisystem Proteinopathy 1.

Objective

Valosin-containing protein (VCP)-associated multisystem proteinopathy 1 (MSP1) is caused by variants in the VCP gene. MSP1 results in various phenotypes including progressive myopathy, Paget's disease of bone, frontotemporal dementia, amyotrophic lateral sclerosis, and parkinsonism...
S-EPMC12257134 | biostudies-literature
UnknownInvestigation of white matter PiB uptake as a marker of white matter integrity.

Objective

To investigate the associations of Pittsburgh compound-B (PiB) uptake in white matter hyperintensities (WMH) and normal appearing white matter (NAWM) with white matter (WM) integrity measured with DTI and cognitive function in cognitively unimpaired older adults.

Methods

Cog...
S-EPMC6469255 | biostudies-literature
UnknownYoung infants display heterogeneous serological responses and extensive but reversible transcriptional changes following initial immunizations.
Infants necessitate vaccinations to prevent life-threatening infections. Our understanding of the infant immune responses to routine vaccines remains limited. We analyzed two cohorts of 2-month-old infants before vaccination, one week, and one-month post-vaccination. We report remarkable heterogenei...
S-EPMC10693608 | biostudies-literature
UnknownAdenotonsillectomy for Snoring and Mild Sleep Apnea in Children: A Randomized Clinical Trial.

Importance

The utility of adenotonsillectomy in children who have habitual snoring without frequent obstructive breathing events (mild sleep-disordered breathing [SDB]) is unknown.

Objectives

To evaluate early adenotonsillectomy compared with watchful waiting and supportive care (watc...
S-EPMC10698619 | biostudies-literature
GenomicsNext Generation Mendelian Genetics: Kabuki Syndrome

The ultimate purpose of this research is to identify genes causing hereditary disorders. We are scaling a new approach to identify the candidate genes and gene mutations that underlie rare human Mendelian (a set of primary tenets relating to the transmission of hereditary characteristics from...

phs000295.v1.p1 | EGA
UnknownVariation in prognosis and treatment outcome in juvenile myoclonic epilepsy: a Biology of Juvenile Myoclonic Epilepsy Consortium proposal for a practical definition and stratified medicine classifications.
Reliable definitions, classifications and prognostic models are the cornerstones of stratified medicine, but none of the current classifications systems in epilepsy address prognostic or outcome issues. Although heterogeneity is widely acknowledged within epilepsy syndromes, the significance of vari...
S-EPMC10288558 | biostudies-literature
UnknownThe Association of Prenatal Dietary Factors with Child Autism Diagnosis and Autism-Related Traits Using a Mixtures Approach: Results from the Environmental Influences on Child Health Outcomes Cohort.

Background

Previous research on the role of maternal diet in relation to autism has focused on examining individual nutrient associations. Few studies have examined associations with multiple nutrients using mixtures approaches, which may better reflect true exposure scenarios.

Objectives...

S-EPMC12264552 | biostudies-literature
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