Sort   by:  
 Page size 
Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
GenomicsIdentification of novel imprinted differentially methylated regions by global analysis of human parthenogenetic induced pluripotent stem cells
Parental imprinting is an epigenetic phenomenon by which genes are expressed in a monoallelic fashion, according to their parent-of-origin. DNA methylation is considered the hallmark mechanism regulating parental imprinting. To identify imprinted differentially methylated regions (DMRs), we compared...
ORGANISM(S): Homo sapiens 
2013-06-12 | E-GEOD-47088 | biostudies-arrayexpress
GenomicsTargeted disruption of DNMT1, 3A and 3B in human embryonic stem cells [DNMT1]
DNA methylation is a key epigenetic modification involved in regulating gene expression and maintaining genomic integrity. Somatic patterns of DNA methylation are largely static, apart from focal dynamics at gene regulatory elements. To further advance our understanding of the role of DNA methylatio...
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-63279 | biostudies-arrayexpress
GenomicsTargeted disruption of DNMT1, 3A and 3B in human embryonic stem cells [DNMT3A/3B DKO]
DNA methylation is a key epigenetic modification involved in regulating gene expression and maintaining genomic integrity. Somatic patterns of DNA methylation are largely static, apart from focal dynamics at gene regulatory elements. To further advance our understanding of the role of DNA methylatio...
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-63280 | biostudies-arrayexpress
GenomicsRRBS profiling of mouse ESCs (wild type and DNMT KOs)
DNA methylation is a key epigenetic modification involved in regulating gene expression and maintaining genomic integrity. Somatic patterns of DNA methylation are largely static, apart from focal dynamics at gene regulatory elements. To further advance our understanding of the role of DNA methylatio...
ORGANISM(S): Mus musculus 
2015-04-13 | E-GEOD-67811 | biostudies-arrayexpress
GenomicsX Chromosome Reactivation Dynamics Reveal Stages of Reprogramming to Pluripotency
Reprogramming to iPSCs resets the epigenome of somatic cells including the reversal of X chromosome-inactivation. We sought to gain insight into the steps underlying the reprogramming process by examining the means by which reprogramming leads to X chromosome-reactivation (XCR). Analyzing single cel...
ORGANISM(S): Mus musculus 
2014-12-18 | E-GEOD-58109 | biostudies-arrayexpress
UnknownContrafreeloading in kea (Nestor notabilis) in comparison to Grey parrots (Psittacus erithacus).
Not available
S-EPMC9579195 | biostudies-literature
GenomicsBI Human Reference Epigenome Mapping Project: Characterization of DNA methylation by RRBS in HUES lines
Characterization of the reference epigenome in humans in a diverse panel of ES cells, tissue stem cells, reprogrammed stem cells, primary cells and tissues **************** For data usage terms and conditions, please refer to: http://www.nida.nih.gov/about/roadmap/epigenomics/data_access_policies.h...
ORGANISM(S): Homo sapiens 
2010-11-11 | E-GEOD-25248 | biostudies-arrayexpress
MetabolomicsSPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids
Characterization of endogenous metabolites and xenobiotics is essential to deconvoluting the genetic and environmental causes of disease. However, surveillance of chemical exposure and disease-related changes in large cohorts requires an analytical platform that offers rapid measurement, high sensit...
2017-02-14 | MTBLS427 | MetaboLights
Sort   by:  
 Page size