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ProteomicsThe human cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally
Cholesterol synthesis is a tightly regulated process, both transcriptionally and post-translationally. Transcriptional control of cholesterol synthesis is relatively well understood. However, of the ~20 enzymes in cholesterol biosynthesis, post-translational regulation has only been examined for a s...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2020-01-15 | PXD016417 | Pride
Dhcr14 Lbr Cholesterol synthesis enzymes 
UnknownMicroRNA Expression-Based Model Indicates Event-Free Survival in Pediatric Acute Myeloid Leukemia.
Not available
S-EPMC5721230 | biostudies-literature
MetabolomicsThe impact of nutritional supplementation on sweat metabolomic content
Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat col...
2021-03-15 | MTBLS2427 | MetaboLights
ProteomicsBC-APPS1: Anti-progestin therapy targets hallmarks of breast cancer risk through epithelial-stromal remodelling
Breast cancer (BC) is the leading cause of women's cancer death worldwide. Here, in the BC – Anti Progestin Prevention Study 1 (BC-APPS1; NCT02408770), we assess whether progesterone receptor antagonism with ulipristal acetate (UA) for 12 weeks reduces surrogate markers of BC risk in 24 premenopausa...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD067122 | Pride
Prevention Breast cancer Laser capture proteomics 
MetabolomicsExperimental and computational approaches for deep metabolome annotation with application to the ecotoxicological model organism Daphnia magna

Identifying metabolomes with greater coverage and confidence is a critical step towards interpreting the metabolic basis of human and environmental health. Yet for over two decades the field of metabolomics has been inhibited by limited metabolite identification. To address this, we developed the...

MTBLS2273 | MetaboLights
ProteomicsEvidence for the nuclear import of monomeric histones H3.1 & H4
We present here evidence that histones H3.1 and H4 can be imported into the nucleus as monomers in human cells. Using a tether-and-release system to study the cytosolic phase and import dynamics of newly synthesised histones, we find that H3.1 and H4 can be maintained as stable monomers in the cytos...
ORGANISM(S): Homo sapiens (Human) 
2018-09-10 | PXD009915 | Pride
Human Histones 
UnknownciliaFA: a research tool for automated, high-throughput measurement of ciliary beat frequency using freely available software.
Not available
S-EPMC3607980 | biostudies-literature
UnknownThe influence of ambulance offload time on 30-day risks of death and re-presentation for patients with chest pain.
Not available
S-EPMC9545565 | biostudies-literature
UnknownAssociation of Socioeconomic Status With Outcomes and Care Quality in Patients Presenting With Undifferentiated Chest Pain in the Setting of Universal Health Care Coverage.
Not available
S-EPMC9075482 | biostudies-literature
UnknownTrial Design and Objectives for Castration-Resistant Prostate Cancer: Updated Recommendations From the Prostate Cancer Clinical Trials Working Group 3.
Not available
S-EPMC4872347 | biostudies-literature
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