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MetabolomicsElevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism
Elevated brain levels of the essential metals manganese (Mn), copper, or iron induce motor disease. However, mechanisms of metal-induced motor disease are unclear and treatments are lacking. Elucidating the mechanisms of Mn-induced motor disease is particularly important because occupational and env...
2025-03-31 | MTBLS975 | MetaboLights
UnknownThe male-type mitochondrial genome of the freshwater mussel Potamilus streckersoni Smith, Johnson, Inoue, Doyle, & Randklev, 2019 (Bivalvia: Unionidae).
Not available
S-EPMC9621207 | biostudies-literature
ProteomicsMetaNetwork Enhances Biological Insights from Quantitative Proteomics Differences by Combining Clustering and Enrichment Analyses
Interpreting proteomics data remains challenging due to the large number of proteins that are quantified by modern mass spectrometry methods. Weighted gene correlation network analysis (WGCNA) can identify groups of biologically related proteins using only protein intensity values by constructing pr...
ORGANISM(S): Homo sapiens (Human) 
2022-01-27 | PXD030784 | Pride
Cancer Analysis Proteomics Prostate Network Human 
TranscriptomicsLong-range expression effects of CNV: insights from Smith-Magenis and Potocki-Lupski syndrome mouse model
To study the effect of structural changes on expression, we assessed gene expression in genomic disorder mouse models. Both a microdeletion and its reciprocal microduplication mapping to mouse chromosome 11 (MMU11), which model the rearrangements present in Smith-Magenis (SMS) and Potocki-Lupski (PT...
ORGANISM(S): Mus musculus 
2010-11-10 | E-GEOD-14802 | biostudies-arrayexpress
GenomicsDifferential methylation between mouse embyronic stem cell states
We generated RRBS data between Rex1-high and Rex1-low cells to identify differentially methylated promoters. We observe bimodal methylation levels in both subpopulations, and that Rex1-low cells accumulate increased levels of methylation, frequently as a function of local CpG density We sorted Rex1 ...
ORGANISM(S): Mus musculus 
2014-07-21 | E-GEOD-58396 | biostudies-arrayexpress
UnknownGene expression associated with disease resistance and long-term growth in a reef-building coral.
Not available
S-EPMC8059587 | biostudies-literature
UnknownBile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates.
Not available
S-EPMC7816163 | biostudies-literature
TranscriptomicsComparison of Zfp706GT and ZfpGT REV ES cells in 2i
Self-renewal circuitry in embryonic stem (ES) cells is increasingly defined. How the robust pluripotency programme is dissolved to enable fate transition is less appreciated. We developed a forward genetic approach using haploid ES cells. We created libraries of transposon integrations and screened ...
ORGANISM(S): Mus musculus 
2014-02-05 | E-GEOD-53194 | biostudies-arrayexpress
UnknownDe novo and inherited TCF20 pathogenic variants are associated with intellectual disability, dysmorphic features, hypotonia, and neurological impairments with similarities to Smith-Magenis syndrome.
Not available
S-EPMC6393995 | biostudies-literature
TranscriptomicsAge Dependent Gene Expression Responses to Inhaled Lipopolysaccharide Combined with Mechanical Ventilation
Children have a lower incidence and mortality from acute lung injury than adults, and infections are the most common event associated with acute lung injury (ALI). To study the effects of age on susceptibility to ALI, we investigated the responses to microbial products combined with mechanical vent...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-18341 | biostudies-arrayexpress
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