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UnknownGas-phase stability of G-quadruplex DNA determined by electrospray ionization tandem mass spectrometry and molecular dynamics simulations.
Not available
S-EPMC2077085 | biostudies-literature
TranscriptomicsRole of IdeR in Iron-Dependent Gene Expression, Iron Metabolism, and Oxidative Stress Response
The mycobacterial IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin repressor) family. In the presence of iron, it binds to a specific DNA sequence in the promoter regions of the genes that it regulates, thus controlling their transcription. In this study, we provide evidence...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-08 | E-GEOD-8732 | biostudies-arrayexpress
TranscriptomicsSupernatants derived from chemotherapy-treated tumours can modify angiogenesis.
The human lung cancer cell line A549 was cultured in media alone, with cyclophosphamide (CPM) or oxaliplatin (OXP) for 72 hours. The exhausted culture media were aspirated and the microvesicular fraction was harvested by sequential ultracentrifugation. RNA was then isolated from microvesicles by Tr...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-TABM-1201 | biostudies-arrayexpress
TranscriptomicsMethanol and Methylamine Utilization Pathways in Methyloversatilis universalis FAM5: Genome Wide Gene Expression and Mutagenesis Studies
Methyloversatilis universalis FAM5 utilizes single carbon compounds such as methanol or methylated amines as a sole source of carbon and energy. Expression profiling reveals distinct sets of genes altered during growth on methanol vs methylamine. Growth on methanol results in activation of mdh2 and ...
ORGANISM(S): Methyloversatilis universalis FAM5 
2014-12-04 | E-GEOD-63822 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis wild type, ideR mutant and ideR complemented mutants strains grown in iron-sufficient or iron-deficient media
The mycobacterial IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin repressor) family. In the presence of iron, it binds to a specific DNA sequence in the promoter regions of the genes that it regulates, thus controlling their transcription. In this study, we provide evidence...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-317 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis wild type and sigH mutant strains after exposure to the thiol-specific oxidizing agent diamide
Like other bacterial species, Mycobacterium tuberculosis has multiple sigma (s) factors encoded in its genome. In previously published work, we and others have shown that mutations in some of these transcriptional activators render M. tuberculosis sensitive to various environmental stresses and, in ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-316 | biostudies-arrayexpress
TranscriptomicsTransposable elements and small RNAs contribute to gene expression divergence between Arabidopsis thaliana and Arabidopsis lyrata
This SuperSeries is composed of the following subset Series: GSE24571: Transposable elements and small RNAs contribute to gene expression divergence between Arabidopsis thaliana and Arabidopsis lyrata [RNA-Seq] GSE38109: Natural variation in Arabidopsis thaliana transcriptomes Refer to individual Se...
ORGANISM(S): Arabidopsis thaliana 
2012-05-21 | E-GEOD-38113 | biostudies-arrayexpress
UnknownPhase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours.
Not available
S-EPMC7251107 | biostudies-literature
UnknownThe genomics education partnership: successful integration of research into laboratory classes at a diverse group of undergraduate institutions.
Not available
S-EPMC2830162 | biostudies-literature
GenomicsGut microbiome modulates response to anti PD1 immunotherapy in metastatic melanoma patients
There is a growing appreciation of the role of the microbiome in cancer, and evidence in pre-clinical models that the gut microbiome may modulate responses to immune checkpoint blockade though this has not been well-characterized in patients. We analyzed the oral (n=86)and gut (n=43) 16S microbiome ...
EGAS00001002698 | EGA
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