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TranscriptomicsPRPF8 CLIP seq for iPSC, kidney organoid, retinal organoid, and retinal epithelium derived from c.6926A>C RPE with Retinitis Pigmentosa patients and CRISPR/Cas9 corrected
Retinitis Pigmentosa is a group of inherited eye disorders characterized by progressive degeneration of photoreceptor cells in the retina, leading to vision loss and eventual blindness. One of the known genetic mutations associated with RP is the c.6926A>C mutation in the RPE (retinal pigment epithe...
ORGANISM(S): Homo sapiens 
2024-03-13 | E-MTAB-13171 | biostudies-arrayexpress
MetabolomicsIntegrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Quantitative mea...
2021-01-29 | MTBLS2014 | MetaboLights
UnknownStructural variation on the human Y chromosome from population-scale resequencing.
Not available
S-EPMC4500966 | biostudies-literature
ProteomicsRBPMS mediates smooth muscle specific alternative splicing via oligomerization and modulation of trans splicing factor recruitment
RBPMS regulates alternative splicing decision via recruiting other trans factors. This experiment aims to investigate the interactome of Strep-II tagged recombinant RBPMS in Hela nuclear extract. The interactome of the full length protein is compared to the construct lacking the far C-terminal 20 am...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037620 | Pride
Human  lc msms  rbpms  ap-ms: splicing factor  rbp 
TranscriptomicsMicroarray analysis of gene expression changes in human A549 lung cancer cells upon siRNA knockdown of FAM60A and SDS3
The Sin3 histone deacetylase (HDAC) complex is a 1.2 MDa chromatin modifying complex that can repress transcription by binding to gene promoters and deacetylating histones. The Sin3/HDAC complex can affect cell cycle progression through multiple mechanisms and is among the targets of anticancer dru...
ORGANISM(S): Homo sapiens 
2012-09-15 | E-GEOD-39733 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon Caco-2 cells treated with sulforaphane (SF)
Effect of sulforaphane (SF) on human colon caco-2 cells after 24h treatment
ORGANISM(S): Homo sapiens 
2005-07-01 | E-MEXP-170 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of dedifferentiating smooth muscle cells from mouse aorta and bladder
Smooth muscle cells (SMCs) are important in a number of physiological systems and organs, including the cardiovascular system. The hallmark property of differentiated SMCs is the ability to contract, but contractile SMCs themselves show a range of phenotypes allowing prolonged tonic contraction in v...
ORGANISM(S): Mus musculus 
2016-07-01 | E-MTAB-4841 | biostudies-arrayexpress
UnknownAn ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis.
Not available
S-EPMC6603039 | biostudies-literature
TranscriptomicsHigh-fat diet induced gene expression changes in mouse retina may be prevented by introducing bilberries in diet
Obesity and diabetes associated visual impairment and vascular dysfunctions are increasing reasons for vision loss. The detailed mechanisms in these diseases are still largely unknown, but mice models have been useful to study these mechanisms and explore the detailed effects of potential compounds....
ORGANISM(S): Mus musculus 
2012-09-08 | E-GEOD-34154 | biostudies-arrayexpress
ProteomicsRBPMS mediates smooth muscle specific alternative splicing via oligomerization and modulation of trans factor recruitment
RBPMS regulate splicing decisions by modulating the transcript-bound proteome. This experiment aims to investigate the proteome assembled on an experimental RNA, TM3 transcript, in human Hela nuclear extract under the various conditions, ± ATP and ± RBPMS. The model RNA is tethered on amylose bead v...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037617 | Pride
Lc ms/ms Rna Alternative splicing factor Human 
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