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TranscriptomicsTranscription profiling of human CD8 T cells in systemic lupus erythematosus (SLE) and vasculitis
Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of the potentially toxic immunosuppressive therapy required for their control. Clinically useful biomarkers have been identified using DNA micr...
ORGANISM(S): Homo sapiens 
2010-06-02 | E-MTAB-157 | biostudies-arrayexpress
TranscriptomicsA Phase Two Randomised Controlled Trial of Belimumab in Kidney Transplant Recipients Demonstrates Comparable Safety, a Reduction in De Novo Antibody Production and an Increase in Regulatory B Cells.
There is an urgent unmet need in solid organ transplantation for immunotherapeutic strategies that target B cells and plasma cells, ideally without increasing infectious complications. We conducted a phase 2 double-blind randomised placebo-controlled trial to assess the safety and potential efficacy...
ORGANISM(S): Homo sapiens 
2018-06-11 | E-MTAB-5906 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse B cells from wild type or mir-155 deficient mice, treated with a-mir155 PNA
B cells were extracted from spleens of mice treated with PNA a-miR155 and vehicle treated mice either wild type or mir-155 deficient. All mice received LPS to induce mir155 expression.
ORGANISM(S): Mus musculus 
2010-03-24 | E-MEXP-2587 | biostudies-arrayexpress
GenomicsEGAS00001000490-sc-20130516 - samples
DNA methylation has been shown to play a major role in determining cellular phenotype by regulating gene expression. Moreover, dysregulation of differentially methylated genes has been implicated in disease pathogenesis of various conditions including cancer development as well as autoimmune disease...
EGAD00001000394 | EGA
GenomicsSequencing component for the whole genome methylation analysis in PBMCs and cell subsets pilot study
DNA methylation has been shown to play a major role in determining cellular phenotype by regulating gene expression. Moreover, dysregulation of differentially methylated genes has been implicated in disease pathogenesis of various conditions including cancer development as well as autoimmune disease...
EGAS00001000490 | EGA
GenomicsIlluminaHumanDT - samples
Genotyping using Illumina Human OmniExpress12v1.0
EGAD00010000748 | EGA
GenomicsLeucocyte eQTLs in autoimmune disease and health
Peripheral blood was taken from healthy controls and patients with active autoimmune disease. CD4 T cells, CD8 T cells, monocytes, neutrophils, and B cells were separated using magnetic-activated cell sorting. RNA and genomic DNA was extracted from cell lysates using Qiagen Allprep kits. Genotyping ...
EGAS00001001251 | EGA
GenomicsLeucocyte eQTLs in autoimmune disease and health
Data Access Committee EGAC00001000338
EGAC00001000338 | EGA
GenomicsDAC for study Sequencing component for the whole genome methylation analysis in PBMCs and cell subsets pilot study 1733-sc-2013-
Data Access Committee EGAC00001000096
EGAC00001000096 | EGA
MetabolomicsLegume rhizodeposition promotes nitrogen fixation by soil microbiota under crop diversification

Biological nitrogen fixation by free-living bacteria and rhizobial symbiosis with legumes plays a key role in sustainable crop production. Here, we study how different crop combinations influence the interaction between peanut plants and their rhizosphere microbiota via metabolite deposition and ...

2024-03-19 | MTBLS6537 | MetaboLights
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