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MetabolomicsRare and common genetic determinants of metabolic individuality and their effects on human health (EPIC-Norfolk study assays)

Garrod’s concept of “chemical individuality” has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput metabolomic technologies provide an in-depth snapshot of human metabolism at scale. We studied the genetic architecture of the human plasma metabolo...

2022-09-09 | MTBLS833 | MetaboLights
TranscriptomicsA Phase Two Randomised Controlled Trial of Belimumab in Kidney Transplant Recipients Demonstrates Comparable Safety, a Reduction in De Novo Antibody Production and an Increase in Regulatory B Cells.
There is an urgent unmet need in solid organ transplantation for immunotherapeutic strategies that target B cells and plasma cells, ideally without increasing infectious complications. We conducted a phase 2 double-blind randomised placebo-controlled trial to assess the safety and potential efficacy...
ORGANISM(S): Homo sapiens 
2018-06-11 | E-MTAB-5906 | biostudies-arrayexpress
UnknownThe Vertebrate Breed Ontology: Toward Effective Breed Data Standardization.
Not available
S-EPMC12103836 | biostudies-literature
UnknownThe Vertebrate Breed Ontology: Towards effective breed data standardization.
Not available
S-EPMC11177956 | biostudies-literature
TranscriptomicsTranscription profiling of Streptomyces coelicolor wild type and phP-null mutants at different time points during phosphate starvation
S. coelicolor was grown in low-phosphate concentration R5 liquid medium which facilitated the transition to a phosphate starvation induced stationary phase and the subsequent induction of the PhoP regulon. Global gene expression profiling of a wild-type and a phoP-null mutant was performed using sam...
ORGANISM(S): Streptomyces coelicolor 
2012-08-30 | E-MAXD-51 | biostudies-arrayexpress
ProteomicsPhospo-proteomic profiling of Castration Resistant Prostate Cancer
The integration of diverse ‘omic’ datasets will increase our understanding of the key signaling pathways that drive disease. Here, we used clinical tissue cohorts corresponding to lethal metastatic castration resistant prostate cancer (CRPC) obtained at rapid autopsy to integrate mutational, transcr...
ORGANISM(S): Homo sapiens (Human) 
2016-08-19 | PXD002286 | Pride
Prostate cancer Human Phosphorylation 
ProteomicsPhospo-proteomic profiling of Castration Resistant Prostate Cancer
The integration of diverse ‘omic’ datasets will increase our understanding of the key signaling pathways that drive disease. Here, we used clinical tissue cohorts corresponding to lethal metastatic castration resistant prostate cancer (CRPC) obtained at rapid autopsy to integrate mutational, transcr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080776 | MassIVE
GenomicsAutozygosity pilot Born in Bradford
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAS00001000462 | EGA
GenomicsEGAS00001000462-sc-20170511 - samples
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAD00001003329 | EGA
GenomicsEGAS00001000462-sc-20141120 - samples
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAD00001001079 | EGA
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