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UnknownCabozantinib in patients with advanced prostate cancer: results of a phase II randomized discontinuation trial.
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S-EPMC4110249 | biostudies-literature
TranscriptomicsNanoString analysis of a rat liver mRNA panel following TCDD treatment
Profiling of mRNA abundances with high-throughput platforms such as microarrays and RNA-Seq has become an important tool in both basic and biomedical research. However these platforms remain prone to systematic errors, and have challenges in clinical and industrial application. As a result it is sta...
ORGANISM(S): Rattus norvegicus 
2013-12-31 | E-GEOD-43251 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Comparison of Neuronal Development Stages using Induced Pluripotent Stem Cells from Bipolar Disorder Patients
Fibroblasts from patients with Type I bipolar disorder (BPD) and their unaffected siblings were obtained from an Old Order Amish pedigree with a high incidence of BPD and reprogrammed to induced pluripotent stem cells (iPSCs). Established iPSCs were subsequently differentiated into neuroprogenitors ...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-74358 | biostudies-arrayexpress
TranscriptomicsInduction of interferon-stimulated genes on the IL-4 response axis by Epstein-Barr virus infected human B cells; relevance to cellular transformation.
Epstein-Barr virus (EBV) is an oncogenic virus that is associated with the pathogenesis of several human lymphoid malignancies, including Hodgkin's lymphoma. Infection of normal resting B cells with EBV results in activation to lymphoblasts that are phenotypically similar to those generated by physi...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-45829 | biostudies-arrayexpress
TranscriptomicsA methyl-deviator epigenotype of estrogen-receptor-positive breast carcinoma is associated with malignant biology
We broadly profiled DNA methylation in breast cancers (n=351) and benign parenchyma (n=47) for correspondence with disease phenotype using formalin-fixed paraffin-embedded (FFPE) diagnostic surgical pathology specimens. Exploratory analysis revealed a distinctive primary invasive carcinoma subclass ...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-29428 | biostudies-arrayexpress
TranscriptomicsOncogenic SDH mutation underlies global epigenomic instability in gastrointestinal stromal tumor
We have discovered a striking connection between mitochondrial dysfunction and epigenomic instability, manifested by global biallelic DNA cytosine 5-methylation and loss of 5-hydroxymethycytosine within succinate dehydrogenase (SDH)-null gastrointestinal stromal tumors (GIST) relative to those beari...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-34387 | biostudies-arrayexpress
TranscriptomicsArray CGH-based Characterization of Genetic Alterations in Pulmonary Neuroendocrine Tumors
The goal of this study was to characterize and classify pulmonary neuroendocrine tumors based on Array Comparative Genomic Hybridization (aCGH). Using aCGH, we performed karyotype analysis of 33 small cell lung cancer (SCLC) tumors, 13 SCLC cell lines, 19 bronchial carcinoids, and 9 gastrointestinal...
ORGANISM(S): Homo sapiens 
2010-04-22 | E-GEOD-21468 | biostudies-arrayexpress
TranscriptomicsSystematic Evaluation of Medium-Throughput mRNA Abundance Platforms
Profiling of mRNA abundances with high-throughput platforms such as microarrays and RNA-Seq has become an important tool in both basic and biomedical research. However these platforms remain prone to systematic errors, and have challenges in clinical and industrial application. As a result it is sta...
ORGANISM(S): Rattus norvegicus 
2012-10-18 | E-GEOD-41388 | biostudies-arrayexpress
TranscriptomicsA mesodermal gene regulatory network directed by zebrafish No tail
Using chromatin immunoprecipitation combined with microarrays we have identified targets of No tail (Ntl), a zebrafish Brachyury ortholog that plays a central role in mesoderm formation. We show that Ntl regulates a downstream network of other transcription factors and identify an in vivo Ntl bindin...
ORGANISM(S): Danio rerio 
2009-02-19 | E-GEOD-12331 | biostudies-arrayexpress
TranscriptomicsGene Expression Changes Associated with Respiratory Muscle Hypertrophy after Intermittent Transient Tracheal Occlusions
The effect of intermittent transient tracheal occlusion (ITTO) on gene expression was compared in the diaphragm and parasternal intercostals. We hypothesized that genes responsible for protein metabolism, myogenic activation, neuromuscular transmission, and inflammatory modulation would be altered i...
ORGANISM(S): Rattus norvegicus 
2012-03-26 | E-GEOD-29574 | biostudies-arrayexpress
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