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Characterization of endogenous metabolites and xenobiotics is essential to deconvoluting the genetic and environmental causes of disease. However, surveillance of chemical exposure and disease-related changes in large cohorts requires an analytical platform that offers rapid measurement, high sensit...
2017-02-14 | MTBLS427 | MetaboLights

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
Identifying sex differences in gene expression within the brain is critical for determining why multiple neurological and behavioural disorders differentially affect males and females. Several are more common or severe in males (e.g., autism and schizophrenia) or females (e.g., Alzheimer’s disease...
ORGANISM(S): Mus musculus 
Proteomics data from cell culture; Treated with wild-type H1N1 and mockulum; 5 biological replicates
ORGANISM(S): Influenza A Virus (a/wilson-smith/1933(h1n1)) (ncbitaxon:381518) Homo Sapiens (ncbitaxon:9606) 
2016-08-04 | MSV000080026 | MassIVE
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
Repurposing chloramphenicol acetyltransferase for a robust and efficient designer ester biosynthesis platform
ORGANISM(S): Clostridium Thermocellum Dsm 1313 (ncbitaxon:637887) Hungateiclostridium Thermocellum (ncbitaxon:1515) 
We utilized a high throughput discovery-based proteomics platform to identify serum peptides and proteins that were associated with the attainment of longevity in a longitudinal study of community-dwelling men age 65 years or older. Baseline serum in 1196 men were analyzed using liquid chromatograph...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-06-19 | MSV000085611 | MassIVE
The Structural Maintenance of Chromosomes (SMC) complexes regulate the chromosome structures essential for proper genome regulation and cell viability. In mammals, the coordinated actions of the SMC complexes condensin I, condensin II and cohesin regulate dynamic chromosome structures throughout th...
ORGANISM(S): Mus musculus 
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