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ProteomicsSMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
Insulin expression is restricted to the pancreatic beta cells, which are physically or functionally depleted in diabetes. Identifying targetable pathways repressing insulin in non-beta cells, particularly in the developmentally related glucagon-secreting alpha cells, is an important aim of regenerat...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-01 | PXD030363 | Pride
Pancreatic islets Chromatin remodelers Alpha cells Beta cells Smndc1 Rnai screen Splicing Insulin transcription 
ProteomicsSMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
Insulin expression is restricted to the pancreatic beta cells, which are physically or functionally depleted in diabetes. Identifying targetable pathways repressing insulin in non-beta cells, particularly in the developmentally related glucagon-secreting alpha cells, is an important aim of regenerat...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-01 | PXD030362 | Pride
Pancreatic islets Chromatin remodelers Alpha cells Beta cells Smndc1 Rnai screen Splicing Insulin transcription 
ProteomicsSMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression
Insulin expression is restricted to the pancreatic beta cells, which are physically or functionally depleted in diabetes. Identifying targetable pathways repressing insulin in non-beta cells, particularly in the developmentally related glucagon-secreting alpha cells, is an important aim of regenerat...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-01 | PXD030361 | Pride
Pancreatic islets Chromatin remodelers Alpha cells Beta cells Smndc1 Rnai screen Splicing Insulin transcription 
TranscriptomicsRNA seq of human breast cancer cell line MDAMB231 with knockdown of splicing factors SRSF7 and SMNDC1
Deep RNA sequencing was performed to investigate the transcriptomic effects of siRNA-mediated knockdown of SRSF7 or SMNDC1 in the triple-negative breast cancer cell line MDA-MB-231. A total of 30 million cells MDA-MB-231 cells were seeded in 6-well plates. The following day, cells were transfected w...
ORGANISM(S): Homo sapiens 
2026-06-01 | E-MTAB-16601 | biostudies-arrayexpress
UnknownPharmacological perturbation of the phase-separating protein SMNDC1.
Not available
S-EPMC10432564 | biostudies-literature
GenomicsEffect of SMNDC1 small molecule inhibition on gene expression
Effect of SMNDC1 small molecule inhibition on gene expression
PRJNA966990 | ENA
GenomicsSMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression [BSA_0337_Smndc1_KD]
SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression [BSA_0337_Smndc1_KD]
PRJNA763588 | ENA
GenomicsSMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression [ATAC-seq]
SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression [ATAC-seq]
PRJNA830490 | ENA
GenomicsSMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression [ChIP-seq]
SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression [ChIP-seq]
PRJNA830489 | ENA
GenomicsSMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression [BSA_0275_SMNDC1]
SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression [BSA_0275_SMNDC1]
PRJNA763587 | ENA
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