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ProteomicsA regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in breast cancer survival
Cytosine deamination to uracil in DNA leads to mutations if the DNA lesion is not corrected. Base excision repair (BER) initiated by single-strand selective uracil-DNA glycosylase 1 (SMUG1) primarily recognizes uracil and oxidized pyrimidines, and processes them to restore the correct bases. SMUG1 s...
ORGANISM(S): Homo sapiens (Human) 
2023-03-09 | PXD025929 | Pride
Smug1 Breast cancer Dna repair Rna and ribonucleoprotein biogenesis Hsa-let-7b-5p Modified bases 
GenomicsSMUG1 promotes telomere maintenance through telomerase RNA end-processing
SMUG1 promotes telomere maintenance through telomerase RNA end-processing
PRJNA479447 | ENA
GenomicsTranscriptome network analysis of Smug1 knock-out cells by using CRISPR/Cas9 system
Transcriptome network analysis of Smug1 knock-out cells by using CRISPR/Cas9 system
PRJNA606327 | ENA
TranscriptomicsSMUG1 promotes telomere maintenance through telomerase RNA end-processing
Single-strand selective uracil DNA-glycosylase (SMUG1) associates with the DKC1-H/ACA ribonucleoprotein complex, which is essential for telomerase biogenesis. We show herein, that SMUG1 interacts with the telomerase RNA component, hTERC, and is required for co-transcriptional processing of the nasce...
ORGANISM(S): Homo sapiens 
2019-08-11 | GSE116580 | GEO
TranscriptomicsTranscriptome network analysis of Smug1 knock-out cells by using CRISPR/Cas9 system
Purpose: To build a differential transcriptome network in Smug1 knock-out HepG2 hepatocarcinoma cells. Methods: Transcriptome analysis by the RNA-seq via mRNA pull-down. Results: We constructed transcriptome from Smug1 knock-out cells by using RNA-seq analysis. Nucleosome and miRNA related genes wer...
ORGANISM(S): Homo sapiens 
2020-06-30 | GSE145210 | GEO
UnknownThe Multiple Cellular Roles of SMUG1 in Genome Maintenance and Cancer.
Not available
S-EPMC7922111 | biostudies-literature
GenomicsMutations in thymic lymphoma tissue of mice deficient in Smug1, Ung and Msh
Mutations in thymic lymphoma tissue of mice deficient in Smug1, Ung and Msh
PRJEB19654 | ENA
TranscriptomicsSmug1 DNA glycosylase modulates the perception of smell in mouse brain through downregulation of olfactory receptor genes
The SMUG1-DNA glycosylase is the primary enzyme responsible for excising 5-hydroxymethyluracil (5hmU) from genomic DNA. SMUG1 activity is high in the brain and is therefore proposed to be particularly important for regulating 5hmU levels in the brain. 5hmU has been proposed as an epigenetic mark, bu...
ORGANISM(S): Mus musculus 
2025-10-20 | GSE274703 | GEO
GenomicsSmug1 DNA glycosylase modulates the perception of smell in mouse brain through downregulation of olfactory receptor genes
Smug1 DNA glycosylase modulates the perception of smell in mouse brain through downregulation of olfactory receptor genes
PRJNA1147682 | ENA
UnknownSmall-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA.
Not available
S-EPMC11846699 | biostudies-literature
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