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ProteomicsMass spectrometry identification data for the interactomics of SMYD3
SMYD3, a member of the SET and MYND domain-containing (SMYD) family, is a histone methyltransferase (HMT) and transcription factor that plays an important role in transcriptional regulation in human carcinogenesis.In an effort to better understanding the mechanistic role of SMYD3, affinity purificat...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031971 | Pride
Hepatocellular carcinoma Smyd3 Igfbp4 Nurd complex Metastasis 
TranscriptomicsGene expression profile for SMYD3 knockdown in esophageal squamous carcinoma cell
SET (Su) and MYND (myeloid-Nervy-DEAF-1) domain-containing protein (SMYD) is a methyltransferase family, including five members of which SMYD1, SMYD2, SMYD3 and SMYD4, has been found to play critical roles in human carcinogenesis. It has been demonstrated that the altered expression of SMYD3 is asso...
ORGANISM(S): Homo sapiens 
2016-08-11 | E-GEOD-85419 | biostudies-arrayexpress
GenomicsSmyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver or colon cancer development
Smyd3 is a histone methyltransferase implicated in tumorigenesis. Here we show that Smyd3 expression in mice is required but not sufficient for chemically induced liver and colon cancer formation. In these organs Smyd3 is functioning in the nucleus as a direct transcriptional activator of several ke...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-67790 | biostudies-arrayexpress
ProteomicsSMYD3: a new regulator of the early steps of adipocyte differentiation
Abstract Background In obesity, adipose tissue undergoes a remodeling process characterized by increased adipocyte size (hypertrophia) and number (hyperplasia). The individual ability to tip the balance toward the hyperplastic growth, with recruitment of new fat cells through adipogenesis, seems to ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-03 | PXD043165 | Pride
Adipose tissue Mice 
GenomicsGene Expression Profiling of siRNA Knockdown and overexpression of SMYD3 in C2C12
Gene Expression Profiling of siRNA Knockdown and overexpression of SMYD3 in C2C12
PRJNA573946 | ENA
GenomicsTargeting Smyd3 by antisense oligonucleotides attenuates liver tumor growth
Targeting Smyd3 by antisense oligonucleotides attenuates liver tumor growth
PRJNA641395 | ENA
GenomicsEffect of SMYD3 on MDA-MB-231 breast cancer cells (RNA-seq)
Effect of SMYD3 on MDA-MB-231 breast cancer cells (RNA-seq)
PRJNA530693 | ENA
TranscriptomicsEffect of SMYD3 on MCF7 breast cancer cells (RNA-seq)
RNA-sequencing analysis of control and SMYD3-overexpressed MCF7 cell lines. SMYD3 (also known as KMT3E), a hisone H3 lysine K4 methyltransferase, is highly expressed in several human cancers, including colorectal and breast carcinomas. Results provide insight into the transcriptional regulation of S...
ORGANISM(S): Homo sapiens 
2022-10-31 | GSE130169 | GEO
GenomicsEffect of pharmacological inhibition of SMYD3 on gene expression in patient-derived CRC-SCs
Effect of pharmacological inhibition of SMYD3 on gene expression in patient-derived CRC-SCs
PRJNA1101506 | ENA
UnknownDiscovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.
Not available
S-EPMC6580565 | biostudies-literature
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