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TranscriptomicsmicroRNA expression profiles of distinct human and mouse mammary epithelial cell types
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-02-20 | E-GEOD-67056 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of normal human mammary cell subpopulations FACS sorted based on expression of CD49f and EpCAM
To delineate epithelial subpopulations in human mammary tissue, hematopoietic and endothelial cells were depleted from freshly isolated cell suspensions derived from reduction mammoplasties by fluorescence-activated cell sorting. The resultant Lin- population was fractionated into four distinct subp...
ORGANISM(S): Homo sapiens 
2010-08-19 | E-GEOD-16997 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of normal mouse mammary cell subpopulations FACS sorted based on expression of biomarkers
To delineate epithelial subpopulations in mouse mammary tissue, hematopoietic and endothelial cells were depleted from freshly isolated cell suspensions derived from mammary glands using fluorescence-activated cell sorting. The resultant Lin- population was fractionated into four distinct subpopulat...
ORGANISM(S): Mus musculus 
2010-03-20 | E-GEOD-19446 | biostudies-arrayexpress
TranscriptomicsExpression data from Ts1Cje and disomic C57BL/6 adult neurospheres
Down syndrome is the most common form of genetic mental retardation. How Trisomy 21 causes mental retardation remains unclear and its effects on adult neurogenesis have not been addressed. To gain insight into the mechanisms causing mental retardation we used microarrays to investigate gene expressi...
ORGANISM(S): Mus musculus 
2010-07-16 | E-GEOD-17760 | biostudies-arrayexpress
TranscriptomicsHDAC Inhibitors induce tumor cell-selective pro-apoptotic transcriptional responses.
The identification of recurrent somatic mutations in genes encoding epigenetic enzymes, coupled with biochemical studies demonstrating aberrant recruitment of epigenetic enzymes such as histone deacetylases (HDACs) and histone methyltransferases (HMTs) to promoter regions through association with on...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-43010 | biostudies-arrayexpress
TranscriptomicsMolecular signature of brain resident memory CD8+ T cells
Tissue resident memory (Trm) represent a newly described memory T cell population. We have previously characterized a population of Trm that persists within the brain following acute virus infection. Although capable of providing marked protection against a subsequent local challenge, brain Trm do n...
ORGANISM(S): Mus musculus 
2012-08-29 | E-GEOD-39152 | biostudies-arrayexpress
TranscriptomicsExpression data from postnatal mouse brain regions of Ts1Cje and disomic C57BL/6 mice.
The Ts1Cje mouse model of Down syndrome (DS) has partial triplication of mouse chromosome 16 (MMU16), which is partially homologous to human chromosome 21. The mouse model develops various neuropathological features identified in DS individuals. We analysed the effect of partial triplication of the ...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-49050 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profiles of distinct human mammary epithelial cell types
RNA samples were prepared from freshly sorted mammary cell subpopulations (MaSC/basal-enriched, luminal progenitor, mature luminal and stromal) from five human donors. High throughput RT-PCR was used to measure the global microRNA expression profiles of each cell subpopulation. The expression profil...
ORGANISM(S): Homo sapiens 
2016-02-20 | E-GEOD-67054 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profiles of distinct mouse mammary epithelial cell types
RNA samples were prepared from freshly sorted mammary cell subpopulations (MaSC/basal-enriched, luminal progenitor, mature luminal and stromal) from five sets of adult mice. High throughput RT-PCR was used to measure the global microRNA expression profiles of each cell subpopulation. The expression ...
ORGANISM(S): Mus musculus 
2016-02-20 | E-GEOD-67055 | biostudies-arrayexpress
TranscriptomicsRNAPII CTD dataset
The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is composed of heptapeptide repeats, which play a key regulatory role in gene expression. Using genetic interaction and mRNA expression analysis we found that truncating the CTD resulted in distinct changes to cellular function. Truncating th...
ORGANISM(S): Saccharomyces cerevisiae 
2013-09-13 | E-GEOD-43120 | biostudies-arrayexpress
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