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MetabolomicsOrganic and Peptidyl Constituents of Snake Venoms: The Picture Is Vastly More Complex Than We Imagined
Small metabolites and peptides in 17 snake venoms (Elapidae, Viperinae, and Crotalinae), were quantified using liquid chromatography-mass spectrometry. Each venom contains >900 metabolites and peptides. Many small organic compounds are present at levels that are probably significant in prey envenoma...
2023-01-11 | MTBLS755 | MetaboLights
ProteomicsAssessing Target Specificity of the Small Molecule Inhibitor Marimastat to Snake Venom Toxins: A Novel Application of Thermal Proteome Profiling
New treatments that circumvent the pitfalls of traditional antivenom therapies are critical to address the problem of snakebite globally. Numerous snake venom toxin inhibitors have shown promising cross-species neutralization of medically significant venom toxins in vivo and in vitro. The developmen...
ORGANISM(S): Crotalus atrox 
2024-06-22 | PXD046399 | Pride
Thermal proteome profiling Snake venom Metalloprotease 
ProteomicsA systemic view of active site specificity profiling of the snake venom metalloprotease HF3 using Proteomic Identification of Cleavage Sites and N-terminomics TAILS
Snake venom metalloproteinases play important roles in the pathological effects of Viperidae venoms including severe local tissue damage, hemorrhage and coagulopathy. Hemorrhagic Factor 3 (HF3), a metalloproteinase isolated from Bothrops jararaca venom, induces severe local hemorrhage. Previous prot...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-29 | PXD009201 | Pride
N-terminome Snake venom metalloprotease Snake venom Hf3 Tails Degradomics 
UnknownThe Unusual Metalloprotease-Rich Venom Proteome of the Australian Elapid Snake Hoplocephalus stephensii.
Not available
S-EPMC9147224 | biostudies-literature
UnknownDifferential evolution and neofunctionalization of snake venom metalloprotease domains.
Not available
S-EPMC3591658 | biostudies-literature
UnknownMechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease.
Not available
S-EPMC6368331 | biostudies-literature
UnknownDifferential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms.
Not available
S-EPMC12737354 | biostudies-literature
UnknownPurification and enzymatic characterization of a novel metalloprotease from Lachesis muta rhombeata snake venom.
Not available
S-EPMC6251203 | biostudies-literature
UnknownCoagulating Colubrids: Evolutionary, Pathophysiological and Biodiscovery Implications of Venom Variations between Boomslang (Dispholidus typus) and Twig Snake (Thelotornis mossambicanus).
Not available
S-EPMC5450719 | biostudies-literature
UnknownSnake venom disintegrins update: insights about new findings.
Not available
S-EPMC10561651 | biostudies-literature
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