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ProteomicsMass Spectrometry Uncovers Protein Interactions and Stoichiometry of Intermediates and Sub-complexes for SNARE Complex Assembly
The neuronal SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 anchored to the presynaptic membrane. It mediates fusion of synaptic vesicles with the presynaptic plasma membrane resulting in exocytosis of neurotransmitters into the synaptic cleft. While the gene...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-25 | PXD030619 | Pride
Native mass spectrometry Chemical cross-linking Snare complex Complexin-1 Signal transmission in neurons 
UnknownMass spectrometry uncovers intermediates and off-pathway complexes for SNARE complex assembly.
Not available
S-EPMC9941103 | biostudies-literature
UnknownConformational change of Syntaxin-3b in regulating SNARE complex assembly in the ribbon synapses.
Not available
S-EPMC9166750 | biostudies-literature
UnknownCanine Salivary Glands: Analysis of Rab and SNARE Protein Expression and SNARE Complex Formation With Diverse Tissue Properties.
Not available
S-EPMC5665109 | biostudies-literature
ProteomicsWDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
The endosomal FYVE- and WD40-domain-containing protein WDFY2 has been assigned a function as tumor suppressor, but its functional mechanism has remained elusive. Here we have used confocal, widefield and super-resolution fluorescence microscopy to show that WDFY2 localizes to the base of retromer-co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-23 | MSV000084122 | MassIVE
UnknownSNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex.
Not available
S-EPMC9216511 | biostudies-literature
UnknownIdentification of the SNARE complex mediating the exocytosis of NMDA receptors.
Not available
S-EPMC5087030 | biostudies-literature
UnknownChemomechanical regulation of SNARE proteins studied with molecular dynamics simulations.
Not available
S-EPMC2920728 | biostudies-literature
UnknownLight-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex.
Not available
S-EPMC10932955 | biostudies-literature
ProteomicsSNAP47 acetylation-dependent regulatory mechanism governing autophagosome-lysosome fusion by modulating the recruitment of HOPS to autophagic vacuoles
Autophagy, a conserved catabolic process implicated in a diverse array of human diseases, requires efficient fusion between autophagosomes and lysosomes to function effectively. Recently, SNAP47 has been identified as a key component of the default SNARE complex mediating autophagosome-lysosome fusi...
ORGANISM(S): Homo Sapiens 
PXD052239 |
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