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ProteomicsCyclin-dependant kinase (CDK) orders the cell cycle via substrate specific thresholds
The appropriate ordering of the cell cycle events in eukaryoates is thought to be brought about by qualitative differences in the substrate specificity of multiple differentially expression Cyclin-CDK complexes. Our analysis of fission yeast supports an alternative quantitative model. Here we report...
ORGANISM(S): Schizosaccharomyces pombe 
2018-04-11 | PXD003598 | Pride
Mass spectrometry Cdk Silac Cell cycle S. pombe 
ProteomicsAnalysis of signaling endosome composition and dynamics using SILAC in embryonic stem cell-derived neurons
Neurons require efficient transport mechanisms such as fast axonal transport to ensure neuronal homeostasis and survival. Neurotrophins and their receptors are conveyed via fast axonal retrograde transport of signaling endosomes to the soma, where they elicit transcriptional responses. Despite the e...
ORGANISM(S): Mus musculus (Mouse) 
2015-12-21 | PXD002111 | Pride
Mass spectrometry Silac Motor neurons Signalling endosomes 
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