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MetabolomicsThe splicing paralogues SNRPB and SNRPN control differential metabolic states

Gene duplication is a major driver of biological complexity, yet the persistence of highly similar paralogous factors suggests the existence of context-dependent functions that remain incompletely understood. Certain conserved components of the mammalian RNA processing machinery exhibit striking ...

2026-02-09 | MTBLS13877 | MetaboLights
GenomicsSNRPB knockdown in GBM
SNRPB knockdown in U251 cells
PRJEB10298 | ENA
ProteomicsProductive mRNA chromatin escape is promoted by PRMT5 methylation of SNRPB
Protein Arginine Methyltransferase 5 (PRMT5) regulates RNA splicing and transcription by symmetrically dimethyl-ates arginine residues (Rme2s/SDMA) in many RNA binding proteins. However, the mechanism by which PRMT5 couples splicing to transcriptional output is unknown. Here, we demonstrate that a m...
ORGANISM(S): Homo sapiens (Human) 
2026-10-26 | PXD054308 | Pride
Prmt5 Transcription Methylation Snrpb Chromatin 
GenomicsTargeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron
Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron
PRJNA1173785 | ENA
TranscriptomicsTargeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron
Dysregulated alternative splicing has been closely linked to the initiation and progression of tumors. Nevertheless, the precise molecular mechanisms through which splicing factors regulate endometrial cancer progression are still not fully understood. This study demonstrated the elevated expression...
ORGANISM(S): Homo sapiens 
2025-03-12 | GSE279656 | GEO
GenomicsRNA sequencing of SNRPA1 and SNRPB knockdown in MDA-LM2 cells
RNA sequencing of SNRPA1 and SNRPB knockdown in MDA-LM2 cells
PRJNA674894 | ENA
UnknownSNRPB promotes the tumorigenic potential of NSCLC in part by regulating RAB26.
Not available
S-EPMC6739327 | biostudies-literature
GenomicsSnrpb, the gene mutated in CCMS, is haploinsufficient and required for proper splicing and morphogenesis
Snrpb, the gene mutated in CCMS, is haploinsufficient and required for proper splicing and morphogenesis
PRJNA748681 | ENA
UnknownSNRPB-mediated RNA splicing drives tumor cell proliferation and stemness in hepatocellular carcinoma.
Not available
S-EPMC7834993 | biostudies-literature
UnknownThe oncogenic role of SNRPB in human tumors: A pan-cancer analysis.
Not available
S-EPMC9582665 | biostudies-literature
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