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TranscriptomicsPlacental Growth Factor/Nrp-1 signaling is required for medulloblstoma growth
Here we present that growth of medulloblastoma is dependent on PlGF/Nrp-1 signaling. PlGF and Nrp-1 are expressed across different molecular subgroups of medulloblastoma. Data presented here are part of a combined molecular effort to subclassify our medulloblastoma cohort according to current molecu...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-37412 | biostudies-arrayexpress
TranscriptomicsDeep Sequencing Identifies IDH1 R132S Mutation in Adult Medulloblastoma (CGH)
Here we present the case of adult medulloblastoma with minimal chromosomal rearrangements. Data presented here are aCGH analyses of two biopsies of adult patient with a medulloblastoma which was classified as a Shh subgroup. Analyses were performed on 2 archival specimens of medulloblastoma, WHO Gra...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-41990 | biostudies-arrayexpress
TranscriptomicsMosaic Amplification of Multiple Receptor Tyrosine Kinase Genes in Glioblastoma
Here we present a novel example of genetic heterogeneity in human malignant brain tumors, in which multiple closely-related driver genes are amplified and activated simultaneously in adjacent intermingled cells. We have observed up to 3 different receptor tyrosine kinases (EGFR, MET, PDGFRA) amplifi...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-33483 | biostudies-arrayexpress
ProteomicsRaphe and Ventrolateral Medulla Proteomics in Sudden Unexplained Death in Childhood with Febrile Seizure History
Sudden unexplained death in childhood (SUDC) is death of a child 12 months old that is unexplained after autopsy and detailed analyses. Among SUDC cases, 28.8% have febrile seizure (FS) history, versus 2-5% in the general population. SUDC cases share features with sudden unexpected death in epilepsy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-12 | MSV000095576 | MassIVE
ProteomicsSupporting MS data for paper (doi:10.1038/s41565-025-02080-2) by Goerzen, D. et al (2025), titled "Machine perception liquid biopsy identifies brain tumours via systemic immune and tumour microenvironment signature"
Supporting MS data for paper (doi:10.1038/s41565-025-02080-2) by Goerzen, D. et al (2025), titled "Machine perception liquid biopsy identifies brain tumors via systemic immune and tumor microenvironment signature." The index of experiments, related MS files, and labels is provided in the uploaded Ex...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-10-13 | MSV000099468 | MassIVE
TranscriptomicsInfant high grade gliomas comprise multiple subgroups characterised by novel targetable gene fusions and better survival
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
2019-08-12 | E-MTAB-7804 | biostudies-arrayexpress
TranscriptomicsInfant high grade gliomas comprise multiple subgroups characterised by novel targetable gene fusions and better survival
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
2019-08-09 | E-MTAB-7802 | biostudies-arrayexpress
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