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TranscriptomicsRoles for ATF6-regulated miRNAs in the ER stress response
We wished to determine the effects of activating the transcription factor, ATF6, on global miRNA expression. We utilized transgenic mice with a conditionally tamoxien-responsive form of ATF6 and assessed cardiac lysates from NTG and TG mice, both treated with tamoxifen and untreated, in order to ide...
ORGANISM(S): Mus musculus 
2012-01-02 | E-GEOD-33515 | biostudies-arrayexpress
TranscriptomicsIdentification and Comparative Analyses of Myocardial miRNAs Involved in Fetal Response to Maternal Obesity
Maternal obesity programs the offspring to cardiovascular disease, insulin resistance, and obesity. We sequenced and profiled the cardiac miRNAs that were dysregulated in the hearts of baboon fetuses born to a high fat / high fructose diet fed mothers compared to a regular diet fed mothers. Fetal he...
ORGANISM(S): Papio hamadryas 
2013-02-01 | E-GEOD-43323 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34 cells isolated from cord blood or peripheral blood transduced with AML1-ETO or empty vector (MIGR1)
Human CD34 cells isolated from cord blood or peripheral blood transduced with AML1-ETO or empty vector (MIGR1).
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-2049 | biostudies-arrayexpress
Transcriptomicsrat small intestine samples
Experiment description 1. Experimental design 1) Authors, laboratory, and contact: Xue-Lin Cui1, Patricia Soteropoulos2, Peter Tolias2, Ronaldo P. Ferraris1: 1Dept. of Pharmacology and Physiology, UMDNJ-New Jersey Medical School, Newark, NJ 07103-2714, 2Center for Applied Genomics, PHRI, 225 Warre...
ORGANISM(S): Rattus norvegicus 
2010-06-09 | E-GEOD-996 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of pig innate immune responses after experimental infection with Actinobacillus pleuropneumoniae
To study hepatic gene expression differences, liver samples from infected pigs (n = 10) were compared with liver samples from the non-infected control group (n = 5). Ten microarrays were performed, such that 5 randomly selected cDNA samples from the infected group were labeled with Oyster 550 (Genis...
ORGANISM(S): Sus scrofa 
2009-09-08 | E-GEOD-11404 | biostudies-arrayexpress
TranscriptomicsHuman GI tract samples of Lactobacillus plantarum 299v
The indigenous human gut microbiota is a major contributor to the human superorganism with established roles in modulating nutritional status, immunity, and systemic health including diabetes and obesity. The complexity of the gut microbiota consisting of over 1012 residents and approximately 1000 s...
ORGANISM(S): Lactobacillus plantarum 
2010-05-16 | E-GEOD-17634 | biostudies-arrayexpress
TranscriptomicsGene expression in mouse thyrotrope adenoma: transcription elongation factor stimulates proliferation
Differential gene expression study comparing choriogonadotropin alpha (Cga) gene deficient and wild type adult mouse pituitary. Thyrotrope hyperplasia and hypertrophy are common responses to primary hypothyroidism. To understand the genetic regulation of these processes, we studied gene expression ...
ORGANISM(S): Mus musculus 
2016-08-05 | E-GEOD-79451 | biostudies-arrayexpress
TranscriptomicsThe Nicotinic alpha6 Subunit Gene Determines Variability in Chronic Pain Sensitivity and Nicotine Anti- allodynia via Cross-inhibition of P2X2/3 Receptors.
We used microarray-based expression genomics in 25 inbred mouse strains to identify dorsal root ganglion (DRG)-expressed genetic contributors to mechanical allodynia a prominent symptom of chronic pain. Expression genetics identifies a role for the Chrna6 (alpha 6-nicotinic receptor) gene in pain in...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-65997 | biostudies-arrayexpress
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