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ProteomicsLate-life restoration of mitochondrial function reverses cardiac dysfunction in old mice
Redox proteomic data from the heart of young mice, old mice, or mice treated with SS31. Quantification of protein-S-glutathionylation was performed using an established redox proteomics workflow. LC-MS/MS raw data were searched with MS-GF+ against the mouse protein sequence database from the Uniprot...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-04-23 | MSV000085329 | MassIVE
ModelsVenkatraman2012 - Interplay between PLS and TSP1 in TGF-β1 activation
Venkatraman2012 - Interplay between PLS and TSP1 in TGF-β1 activation The interplay between PLS (Plasmin) and TSP1 (Thrombospondin-1) in TGF-β1 (Transforming growth factor-β1)is shown using mathematical modelling and in vitro experimentents. ...
2024-09-02 | BIOMD0000000447 | BioModels
TranscriptomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer. [human]
The ets transcription factor ELF5 specifies the differentiation of mammary progenitor cells to establish the milk-secreting lineage. ER- and poor prognosis basal breast cancers arise from this progenitor cell and these cancers express high levels of Elf5. Knockdown of ELF5 expression in basal breast...
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-30405 | biostudies-arrayexpress
ProteomicsLate-life restoration of mitochondrial function reverses cardiac dysfunction in old mice
Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We show here that 8-week treatment of old mice with the mitochondrial targeted peptide SS-31 (elamipretide) can substantially reverse this deficit. SS-31 normalized the increase in proton leak and reduced mitochon...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-17 | MSV000084961 | MassIVE
TranscriptomicsProfiling the transcriptome of the adult mouse skeleton: RNA-seq of osteocytes from tibiae, femora, humeri and calvariae
In this experiment we define the transcriptome of the adult mouse skeleton by performing total-RNA transcriptome-sequencing on osteocytes, the critical regulatory cells in bone. Osteocytes from 16 week-old male mice (n=8) were isolated for 4 bone types across the skeleton: the tibia, femur, humerus,...
ORGANISM(S): Mus musculus 
2020-12-16 | E-MTAB-5532 | biostudies-arrayexpress
TranscriptomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-30407 | biostudies-arrayexpress
TranscriptomicsDifferences in the osteocyte-specific transcriptome in the presence of multiple-myeloma tumour burden
Skeletal homeostasis if profoundly altered in response to multiple-myeloma tumour burden. Osteocytes are pivotal regulatory cells in skeletal homeostasis. This dataset was used to examine the differences in the osteocyte-specific transcriptome that may underlie the changes in skeletal homeostasis th...
ORGANISM(S): Mus musculus 
2023-12-31 | E-MTAB-5555 | biostudies-arrayexpress
GenomicsEGAD00000000056
WTCCC project samples from the primary biliary cirrhosis cohort
EGAD00000000056 | EGA
GenomicsWTCCC3 case-control study for Primary Biliary Cirrhosis
Genome-wide association scan was performed in 1,840 cases of primary biliary cirrhosis and 5,163 controls. Replication of new associations was tested in an independent set of 620 cases and 2,514 controls.
EGAS00000000039 | EGA
UnknownOncogenic Signaling Pathways in The Cancer Genome Atlas.
Not available
S-EPMC6070353 | biostudies-literature
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