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TranscriptomicsTranscription profiling of fission yeast SAGA mutants shows that the SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8
The SAGA complex is a conserved multifunctional coactivator known to play broad roles in eukaryotic transcription. To gain new insights into its functions, we have performed biochemical and genetic analyses of SAGA in the fission yeast, Schizosaccharomyces pombe. Purification of the S. pombe SAGA ...
ORGANISM(S): Schizosaccharomyces pombe 
2008-11-19 | E-MTAB-53 | biostudies-arrayexpress
UnknownLow-Background Acyl-Biotinyl Exchange Largely Eliminates the Coisolation of Non-S-Acylated Proteins and Enables Deep S-Acylproteomic Analysis.
Not available
S-EPMC7451198 | biostudies-literature
TranscriptomicsTranscription profiling of fission yeast strains identifies widespread requirement for SWI/SNF and RSC on transcription
SWI/SNF chromatin remodeling complexes play critical roles in transcription and other chromatin-related processes. The analysis of the two members of this class in Saccharomyces cerevisiae, SWI/SNF and RSC, has heavily contributed to our understanding of these complexes. To understand the in vivo ...
ORGANISM(S): Schizosaccharomyces pombe 
2008-06-13 | E-MTAB-31 | biostudies-arrayexpress
MetabolomicsA Multi-Omic View of Host-Pathogen-Commensal Interplay in Salmonella-Mediated Intestinal Infection
The potential for commensal microorganisms indigenous to a host (the microbiome or microbiota) to alter infection outcome by influencing host-pathogen interplay is largely unknown. We used a multi-omics systems approach, incorporating proteomics, metabolomics, glycomics, and metagenomics, to explore...
2014-06-24 | MTBLS96 | MetaboLights
TranscriptomicsRNA-Seq of yeast FBY107, FBY106 strains to investigate pre-mRNA degradation pathway
General discard pathways eliminate unprocessed and irregular pre-mRNAs to control the quality of gene expression. In contrast to such general pre-mRNA decay, we describe here a nuclear pre-mRNA degradation pathway that controls the expression of select intron-containing genes. We show that the fissi...
ORGANISM(S): Schizosaccharomyces pombe 
2012-02-10 | E-MTAB-708 | biostudies-arrayexpress
GenomicsRNA-seq and RRBS of developing zebrafish larval brain and WGBS of 4 week old WT and dnmt3aa/dnmt3ab CRISPR/CAS9 KO brain
DNA methylation predominantly occurs at CG dinucleotides in vertebrate genomes, however, non-CG methylation (mCH) is also detectable in vertebrate tissues, most notably in the nervous system. In mammalian brains, it is well established that: i) mCH is targeted to CAC trinucleotides by DNMT3A, ii) en...
ORGANISM(S): Danio rerio 
2020-12-18 | E-MTAB-9924 | biostudies-arrayexpress
ProteomicsProteomic analysis of rainbow trout (Oncorhynchus mykiss) exposed to microplastics
The pollution of the environment with microplastics has been recognized as an emerging threat worldwide. Due to an exponential increase in production of plastic over the last eight decades and its longevity in the environment, accumulating amounts of microplastic are polluting rivers, lakes and the ...
ORGANISM(S): Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 
2022-08-08 | PXD033331 | Pride
Q exactive hf-x Liver Oncorhynchus mykiss Microplastics Rainbow trout 
UnknownApproaches for patients with very high MELD scores.
Not available
S-EPMC7001538 | biostudies-literature
no omics definedA coordintate global control over cellular transcription
Although much is known about the regulation of eukaryotic transcription, the global controls which determine rates of total transcription within a cell are not well understood. We have investigated the effects that the DNA to protein ratio has on both total cellular transcription and the transcripti...
ORGANISM(S): Schizosaccharomyces pombe 
2011-09-23 | E-TABM-1075 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Salmonella enterica (I) serovar Typhi Ty2 wild type and ompR null strains in a strand-specific manner
Analysis of transcriptome in a strand-specific manner to further refine previous genome annotation; RNA-seq was also combined with microarray and proteome analysis to further define the S. Typhi ompR regulon and identify novel ompR regulated transcripts.
ORGANISM(S): Salmonella enterica 
2009-03-03 | E-TABM-644 | biostudies-arrayexpress
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