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MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
UnknownVision-Related Quality of Life in Patients with Optic Neuropathy: Insights from a Portuguese Single Center Using the NEI-VFQ-25.
Not available
S-EPMC12655186 | biostudies-literature
UnknownA cluster randomized trial of a multifaceted quality improvement intervention in Brazilian intensive care units: study protocol.
Not available
S-EPMC4342101 | biostudies-literature
UnknownNon-pharmacological interventions in primary care to improve the quality of life of older patients with palliative care needs: a systematic review protocol.
Not available
S-EPMC9073414 | biostudies-literature
UnknownEnhanced mercury phytoremediation by Pseudomonodictys pantanalensis sp. nov. A73 and Westerdykella aquatica P71.
Not available
S-EPMC10235320 | biostudies-literature
UnknownNovel Exosome Biomarker Candidates for Alzheimer's Disease Unravelled Through Mass Spectrometry Analysis.
Not available
S-EPMC9016047 | biostudies-literature
UnknownThe Liberfarb syndrome, a multisystem disorder affecting eye, ear, bone, and brain development, is caused by a founder pathogenic variant in thePISD gene.
Not available
S-EPMC6892740 | biostudies-literature
TranscriptomicsGene expression profile of classical Hodgkin lymphoma according to Epstein-Barr infection status
Transcriptional profiling of Human Hodkin Lymphoma lineages infected or not by Epstein Baar Virus (EBV). We compared EBV infected lineage L591 and not EBV infected lineages L428, L1236 and KMH2. Goal was to determine presence versus absence of EBV infection on global gene expression of Hodkin Lymp...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-21586 | biostudies-arrayexpress
UnknownMulticentric standardization of minimal/measurable residual disease in B-cell precursor acute lymphoblastic leukaemia using next-generation flow cytometry in a low/middle-level income country.
Not available
S-EPMC10091773 | biostudies-literature
UnknownValidation of a Novel, Sensitive, and Specific Urine-Based Test for Recurrence Surveillance of Patients With Non-Muscle-Invasive Bladder Cancer in a Comprehensive Multicenter Study.
Not available
S-EPMC6930177 | biostudies-literature
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