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ProteomicsIdentifying the mitotic interactome of the human PLK1 protein kinase
The project mapped the interactors of PLK1 in cells were the endogenous PLK1 locus was tagged with 3xHA tags. Cells were arrested in mitosis with nocodazole and treated with a PLK1 inhibitor (BI-2536) to trap PLK1 onto its substrates, facilitating detection by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2026-07-03 | PXD080479 | Pride
Plk1 mitotic interactome 
MetabolomicsGeographic variation of mutagenic exposures in kidney cancer genomes

International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden1. This pertains to clear cell renal cell carcinoma (ccRCC), fo...

2024-03-26 | MTBLS9394 | MetaboLights
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