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TranscriptomicsGene expression profiling of prefrontal cortices of mice subjected to acute and chronic social stress
In order to better understand the effects of social stress on the prefrontal cortex, we investigated gene expression in mice subjected to acute and repeated social encounters of different duration using microarrays. The observed up-regulation of genes associated with vascular system and brain injury...
ORGANISM(S): Mus musculus 
2015-01-07 | E-GEOD-64734 | biostudies-arrayexpress
TranscriptomicsBrain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder
Social stress mouse models were used to simulate human post-traumatic stress disorder (PTSD). C57B/6 mice exposed to SJL aggressor mice exhibited behaviors accepted as PTSD-in-mouse phenotype: 'frozen' motion, aggressor’s barrier avoidance, startled jumping, and retarded locomotion. Transcripts in...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-45035 | biostudies-arrayexpress
MetabolomicsER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis
The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
TranscriptomicsExpression data from ileum of mice suffered from subchronic and mild social defeat stress
This study aimed to investigate the effects of depression on transcriptome in ileum using a subchronic and mild social defeat stress (sCSDS) model. In addition to exhibiting social deficit and hyperphagia-like behavior, the sCSDS mice keep much more water in their body than control mice. In order to...
ORGANISM(S): Mus musculus 
2016-08-03 | E-GEOD-64004 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of spleen, blood and hemi-brain of social stressed C57B6 mice exhibiting PTSD like features
Social stress mouse models were used to simulate human post-traumatic stress disorder (PTSD). C57B/6 mice exposed to SJL aggressor mice exhibited behaviors accepted as PTSD-in-mouse phenotype: 'frozen' motion, aggressor's barrier avoidance, startled jumping, and retarded locomotion. Transcripts in s...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-68076 | biostudies-arrayexpress
ProteomicsHypothalamic protein profiling from mice subjected to social defeat stress
We have analysed changes in the hypothalamus using iTRAQ proteomics 4 plex from mice exposed to social defeat protocol using Qexactive and Orbitrap Velos
ORGANISM(S): Mus musculus (Mouse) 
2024-05-28 | PXD005644 | Pride
Hypothalamus Stress Social defeat 
TranscriptomicsTranscriptome characterization of social stressed C57B6 mice exhibiting PTSD like features
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-68077 | biostudies-arrayexpress
MetabolomicsCoordinate Regulation of Metabolite Glycosylation and Stress Hormone Biosynthesis by TT8 in Arabidopsis
Secondary metabolites play a key role in coordinating ecology and defense strategies of plants. Diversity of these metabolites arise by conjugation of core structures with diverse chemical moieties, such as sugars in glycosylation. Active pools of phytohormones, including those involved in plant str...
2016-10-03 | MTBLS129 | MetaboLights
TranscriptomicsTranscription profiling of mouse liver from animals exposed to social stress
Social stress is well known to be involved in the occurrence and exacerbation of mental illness, and also various life-style related diseases such as hyperinsulinemia, hyperglycemia, cardiovascular diseases and cancer. However, there is little information on tissue-specific gene expression in respon...
ORGANISM(S): Mus musculus 
2009-04-19 | E-GEOD-12693 | biostudies-arrayexpress
GenomicsBAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli
ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the n...
ORGANISM(S): Mus musculus 
2016-07-30 | E-GEOD-85005 | biostudies-arrayexpress
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