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TranscriptomicsSOCS2 expression correlates with tumor malignancy, exerts growth promoting effects and is enhanced by androgens in prostate cancer
Deregulation of cytokine- and growth factor signaling due to altered expression of endogenous regulators is well recognized in prostate and other cancers. Suppressor of cytokine signaling 2 (SOCS2) is a key regulator of growth hormone, IGF and prolactin signaling, that have been implicated in carcin...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-50936 | biostudies-arrayexpress
TranscriptomicsAffect of Socs2 loss-of-function on liver regeneration
SOCS2 Ensures Metabolic Function and Mass Restoration During Liver Regeneration - SOCS2 plays distinct and contrasting roles during liver regeneration. Early after injury, SOCS2 expression increases and limits the rate of regeneration, preserving metabolic activity. Surprisingly, at later times, t...
ORGANISM(S): Mus musculus 
2014-02-01 | E-GEOD-51801 | biostudies-arrayexpress
GenomicsEffect of SOCS2 R96C mutation on mouse mammary gland development and function
Effect of SOCS2 R96C mutation on mouse mammary gland development and function
PRJNA935704 | ENA
GenomicsSOCS2 contributes to reduction of the third digit during development of the chicken forelimb
SOCS2 contributes to reduction of the third digit during development of the chicken forelimb
PRJNA1061522 | ENA
TranscriptomicsAffect of Socs2 loss-of-function on liver regeneration
SOCS2 Ensures Metabolic Function and Mass Restoration During Liver Regeneration - SOCS2 plays distinct and contrasting roles during liver regeneration. Early after injury, SOCS2 expression increases and limits the rate of regeneration, preserving metabolic activity. Surprisingly, at later times, the...
ORGANISM(S): Mus musculus 
2014-02-01 | GSE51801 | GEO
UnknownKIAA0317 regulates pulmonary inflammation through SOCS2 degradation.
Not available
S-EPMC6795399 | biostudies-literature
UnknownIL-1β Induces SOCS2 Expression in Human Dendritic Cells.
Not available
S-EPMC6928683 | biostudies-literature
UnknownSOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms.
Not available
S-EPMC5589800 | biostudies-literature
TranscriptomicsEffect of SOCS2 R96C mutation on mouse mammary gland development and function
The R96C mutation in SOCS2 (suppressor of cytokine signaling 2) that leads to greater milk production but also a greater sensitivity to mastitis was identified in Lacaune sheep by Rupp et al, 2015. This mutation leads to a loss of ligand recognition for SOCS2 and thus interferes with JAK/STAT signal...
ORGANISM(S): Mus musculus 
2024-02-26 | GSE225441 | GEO
UnknownSOCS2 negatively regulates growth hormone action in vitro and in vivo.
Not available
S-EPMC546423 | biostudies-literature
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