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TranscriptomicsTranscription profiling of mouse liver regeneration in Socs3 h-KO mice, Socs3 fl/fl, Alb-Cre- littermates controls
Suppressor of cytokine signaling 3 (SOCS3) down-regulates several signaling pathways in multiple cell types, and previous data suggest that SOCS3 may shut off cytokine activation at the early stages of liver regeneration. We developed hepatocyte-specific Socs3 knockout (Socs3 h-KO) mice to directly ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9549 | biostudies-arrayexpress
ProteomicsAblation of SOCS3 in Cardiomyocytes Exacerbates Cardiac hypertrophy and Dysfunction by Increasing GRP78-medieated ER Stress after pressure overload
To explore the mechanisms for SOCS3 in cardiomyocytes to regulate cardiac hypertrophic remodeling after pressure overload, we therefore performed proteomic analysis to identify novel protein targets or pathways in left ventricular samples from SOCS3 knockout (SOCS3cko) mice and their WT littermates.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD014946 | Pride
Socs3 knockout mice Mouse Heart tissues 
TranscriptomicsSustained axon regeneration induced by a synergy of PTEN and SOCS3 deletion
A formidable challenge in neural repair in the adult central nervous system (CNS) is the long distances that regenerating axons often need to travel in order to reconnect with their targets. Thus, a sustained capacity for axon regeneration is critical for achieving functional restoration. Although d...
ORGANISM(S): Mus musculus 
2011-10-27 | E-GEOD-32309 | biostudies-arrayexpress
GenomicsGenetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic Dissection in Mice
Genetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic Dissection in Mice
PRJNA612890 | ENA
GenomicsSingle-cell RNAseq analysis of wild type and Socs3 cKO retinal immune cells
Single-cell RNAseq analysis of wild type and Socs3 cKO retinal immune cells
PRJNA947200 | ENA
TranscriptomicsSingle-cell RNAseq analysis of wild type and Socs3 cKO retinal immune cells
Myeloid SOCS3 deficiency leads to increased retinal neovascularization in an oxygen-induced retinopathy mouse model. To investigate the role of SOCS3 in the function of myeloid lineage cells, particular microglia during retinopathy, total immune cells were sorted from wildtype and myeloid Socs3 knoc...
ORGANISM(S): Mus musculus 
2024-02-25 | GSE227861 | GEO
TranscriptomicsInsights into gene expression profiles induced by Socs3 depletion in Keratinocytes
Specific deletion of suppressor of cytokine signaling 3 (Socs3) in keratinocytes can cause severe skin inflammation with infiltration of immune cells, however the molecular mechanisms and key regulatory pathways involved remains poorly understood. To investigate the role of Socs3 in keratinocytes, w...
ORGANISM(S): Mus musculus 
2018-02-01 | GSE94743 | GEO
UnknownObesity Attenuates Ventilator-Induced Lung Injury by Modulating the STAT3-SOCS3 Pathway.
Not available
S-EPMC8417798 | biostudies-literature
UnknownSOCS3 inhibits the mesenchymal stromal cell secretory factor SDF-1-mediated improvement of islet function in non-obese diabetic mice.
Not available
S-EPMC10318645 | biostudies-literature
UnknownSOCS3 deletion promotes optic nerve regeneration in vivo.
Not available
S-EPMC2796263 | biostudies-literature
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