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TranscriptomicsmiRNA expression in fast and slow skeletal muscle of wild type and SOD1-G93A mice
Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease that progressively debilitates neuronal cells that control voluntary muscle activity. In a mouse model of ALS that expresses mutated human superoxide dismutase 1 (SOD1-G93A) skeletal muscle is one of the tissues affected early by m...
ORGANISM(S): Mus musculus 
2014-03-04 | E-GEOD-55507 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse motorneurons during progression of the disease in transgenic SOD1(G93A) mice that develop motorneuron loss
To identify candidate genes that may be involved in motoneuron degeneration, we combined laser capture microdissection with microarray technology. Gene expression in motoneurons was analyzed during the progression of the disease in transgenic SOD1(G93A) mice that develop motoneuron loss. Three major...
ORGANISM(S): Mus musculus 
2005-10-30 | E-MEXP-453 | biostudies-arrayexpress
ProteomicsCharacterization and chemoproteomic profiling of protein O-GlcNAcylation in SOD1-G93A mouse model
ALS is a devastating motor neuron disease. Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification has been found to affect the processing of several important proteins implicated in ALS. However, the O-GlcNAcylated proteome remains unexplored during ALS progression. Herein, we probed the dyn...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD059664 | Pride
Amyotrophic lateral sclerosis (als) Sod1-g93a mice O-linked β-n-acetylglucosamine (o-glcnac) Lc-ms/ms 
GenomicsscRNAseq from spinal cords of SOD1-G93A and WT mice
scRNAseq from spinal cords of SOD1-G93A and WT mice
PRJNA703843 | ENA
ProteomicsCNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1
Extracellular vesicles (EVs) are secreted by myriad cells in culture and also by unicellular organisms, and their identification in mammalian fluids suggests that EV release also occurs at the organism level. However, although it is clearly important to better understand EVs' roles in organismal...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-11 | PXD021396 | Pride
Exosome (vesicle) Secretion Mouse model Proteomics Protein homeostasis Amyotrophic lateral sclerosis (als) (lou gehrig disease) Extracellular vesicles Central nervous system (cns) Neurodegeneration Astrocyte 
TranscriptomicsExpression data from mutant SOD1(G93A) transgenic mice
Expression profiling of spinal cord from SOD1(G93A) mice and age matched controls at ages 28, 42, 56, 70,98,112, and 126 days of age. We used microarrays to determine differential gene expression throughout disease progression in the spinal cord of mutant SOD1(G93A) model of ALS. Samples were collec...
ORGANISM(S): Mus musculus 
2009-10-17 | E-GEOD-18597 | biostudies-arrayexpress
TranscriptomicsProfiling wt SOD versus ALS SOD1(G93A) mutant
Whole-genome profiling of SH-SY5Y cells was done on neuroblastoma SH-SY5Y stably transfected with cDNAs coding for SOD1WT or the mutant SOD1(G93A) protein. Five wt SOD versus five mutant SOD
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-21298 | biostudies-arrayexpress
GenomicsCortical glia in SOD1(G93A) mice are subtly affected by ALS-like pathology
Cortical glia in SOD1(G93A) mice are subtly affected by ALS-like pathology
PRJNA850174 | ENA
GenomicsRNA-Seq result of Bulk spinal cord of SOD1*G93A transgenic mice treated with PF-04457845 or vehicle
RNA-Seq result of Bulk spinal cord of SOD1*G93A transgenic mice treated with PF-04457845 or vehicle
PRJNA1015587 | ENA
TranscriptomicsExpression data from mutant SOD1(G93A) transgenic mice
Expression profiling of spinal cord from SOD1(G93A) mice and age matched controls at ages 28, 42, 56, 70,98,112, and 126 days of age. We used microarrays to determine differential gene expression throughout disease progression in the spinal cord of mutant SOD1(G93A) model of ALS.
ORGANISM(S): Mus musculus 
2009-10-17 | GSE18597 | GEO
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