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MetabolomicsIntegrated transcriptome and metabolome analysis reveals the regulatory mechanism underlying fluoride tolerance in XSKD silkworm strain
XueSong KD (XSKD) is a fluoride-tolerant Bombyx mori strain that grows normally under long-term fluoride exposure, whereas its molecular tolerance mechanism remains elusive. Herein, we performed combined transcriptomic and untargeted metabolomic profiling using pre-molt fourth-instar XSKD larvae fed...
2026-07-07 | MTBLS14966 | MetaboLights
TranscriptomicsGene expression profiling of HOS (human osteosarcoma) cells exposed to fluoride
Though fluoride is considered an essential trace element, chronic exposure to fluoride is known to cause toxic effects. Chronic exposure of high concentration of fluoride may leads to fluorosis. To understand the molecular mechanism of fluoride induced toxicity gene expression profiling was performe...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-70719 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profile in HOS cells exposed to sodium fluoride
Fluorosis is caused due to excess of fluoride intake over a long period of time. Aberrant change in RUNX2-mediated signaling cascade is one of the decisive steps during the pathogenesis of fluorosis. Till date, role of fluoride on the epigenetic alterations is not studied. In the present study, glob...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-57550 | biostudies-arrayexpress
ProteomicsA molecular insight into fluoride toxicity in skeletal muscle using invitro C2C12 and in vivo C57BL/6 mice models
Fluoride toxicity in multiple organs has been extensively reported in several decades of research. In-depth study coverage is available on teeth and bone tissues. But studies addressing skeletal muscle fluorosis are scanty. C57BL/6 mice were provided with sodium fluoride in drinking water for 60 day...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035014 | Pride
Mus musculus Skeletal muscle Sodium fluoride Orbitrap Lc-ms/ms 
TranscriptomicsThe differentially expressed genes of A. ferrooxidans ATCC 23270 at different time after introduced fluoride
The deleterious fluoride ions, which released from fluoride in uranium during its bioleaching, strongly influenced microbial growth, energy intake, enzyme activity and relative metabolism. Whole-genome microarrays were used to obtain a comprehensive description of the molecular response by A. ferroo...
ORGANISM(S): Acidithiobacillus ferrooxidans ATCC 23270 
2016-07-03 | E-GEOD-76450 | biostudies-arrayexpress
TranscriptomicsIdentification of genes involved in apoptosis induced by sodium fluoride in rat oral epithelial cells
Although an appropriate range of fluoride is thought to be safe and effective, excessive fluoride intake results in toxic effects in either hard tissues of teeth and skeleton or soft tissues of kidney, lung and brain. It is also well known that fluoride at a millimolar range elicits the complex cell...
ORGANISM(S): Rattus norvegicus 
2014-01-09 | E-GEOD-53937 | biostudies-arrayexpress
GenomicsFluoride effects
EFFECTS OF SODIUM FLUORIDE OVER ORAL BACTERIAL BIOFILMS COMPOSITION AND ACTIVITY
PRJEB35662 | ENA
TranscriptomicsRNA-Seq of FEX1, FEX2 deleted S. cerevisiae (yeast) treated with sodium fluoride against untreated control
Fluoride is a highly abundant, naturally occurring toxicant that causes oxidative stress, cell cycle arrest, and apoptosis at high concentrations. Our lab has created a fluoride-sensitized yeast model lacking fluoride exporters, FEX1 and FEX2. These yeast undergo cell cycle arrest and apoptosis at o...
ORGANISM(S): Saccharomyces cerevisiae 
2021-12-02 | E-MTAB-8061 | biostudies-arrayexpress
TranscriptomicsIdentification of genes involved in cell death induced by sodium fluoride in rat oral epithelial cells
Although an appropriate range of fluoride is thought to be safe and effective, excessive fluoride intake results in toxic effects in either hard tissues of teeth and skeleton or soft tissues of kidney, lung and brain. It is also well known that fluoride at a millimolar range elicits the complex cell...
ORGANISM(S): Rattus norvegicus 
2014-01-09 | GSE53937 | GEO
Genomics
The effects of sodium fluoride on the oral microbiota
PRJNA911028 | ENA
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