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TranscriptomicsTranscription profiling of mouse control 25-dpc embryos from control vs. valproic acid (VPA) treated dams and control P19 mouse EC cells vs 1 mM sodium valproate for 24 h
Valproic acid (VPA) is a potent inducer of neural tube defects (NTDs), but its mechanism of teratogenicity is not known. To study the transcriptional response of VPA during the susceptible period, i.e. when VPA is likely to exert most of its teratogenic effect, RNA was extracted from 8.25-dpc embryo...
ORGANISM(S): Mus musculus 
2004-08-01 | E-MEXP-45 | biostudies-arrayexpress
ProteomicsSodium valproate is protective in a transgenic zebrafish model of Machado Joseph disease
The neurodegenerative disease Machado Joseph disease (MJD, also known as spinocerebellar ataxia-3) is a fatal disease that impairs control and co-ordination of movement. MJD is caused by expansion of a trinucleotide (CAG) repeat region within the ATXN3 gene, encoding a long polyglutamine (polyQ) reg...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2021-08-23 | PXD009612 | Pride
Ataxin-3 Label-free quantitative proteomics Machado joseph disease Polyq Zebrafish 
no omics definedTranscription profiling of mouse pluripotent embryocarcinoma cell line P19 after sodium valproate treatment to investigate its mechanism of teratogenicity
In the process of evaluating teratogenic properties of xenobiotica, the consumption of laboratory animals is high and costly which makes the development of alternative methods desirable. The pluripotent embryocarcinoma cell line P19, which closely resembles the early stage of an embryo, may be relev...
ORGANISM(S): Mus musculus 
2008-01-23 | E-MEXP-981 | biostudies-arrayexpress
no omics definedTranscription profiling of mouse embryos 1.5, 3 and 6 hr after maternal treatment with the teratogen sodium valproate
The antiepileptic drug valproic acid (vpa) is known teratogen giving neural tube defects (ntd:s). Administration of vpa to female NMRI on gestation day 8 induces a high incidence of ntd. In this study we investigate the time dependent gene expression changes induced in the embryo 1.5, 3 respectively...
ORGANISM(S): Mus musculus 
2008-03-28 | E-MEXP-1062 | biostudies-arrayexpress
TranscriptomicsEffect of Sodium Valproate on Rat Primary Hepatocytes.
This study provides an evaluation of changes in gene expression associated with sodium valproate treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses (500 uM and 10 mM) of sodium valproate and water vehicle control. Five replicates of each t...
ORGANISM(S): Rattus norvegicus 
2012-08-28 | E-GEOD-40338 | biostudies-arrayexpress
TranscriptomicsProfile of gene expression in K562 cells exposed to 2 mM sodium valproate for 12 hours using Agilent SurePrint G3 Human GE 8x60K Microarray.
To explore the mechanism underlying anti-leukaemia effect of sodium valproate, the growth and survival of the K562 cell line were investigated using the Annexin V/PI dual staining method. Global profiles of gene expression in K562 cells exposed to sodium valproate were assessed using gene expression...
ORGANISM(S): Homo sapiens 
2011-11-11 | E-GEOD-32189 | biostudies-arrayexpress
TranscriptomicsEffect of Sodium Valproate on Rat Primary Hepatocytes.
This study provides an evaluation of changes in gene expression associated with sodium valproate treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses (500 uM and 10 mM) of sodium valproate and water vehicle control. Five replicates of each tr...
ORGANISM(S): Rattus norvegicus 
2012-08-28 | GSE40338 | GEO
TranscriptomicsmiRNA expression profiling in neural differentiated mouse embryonic stem cells (mESCs) under exposure to sodium valproate and sodium arsenite
Studying chemical disturbances during neural differentiation of mES cells has been established as an alternative in vitro testing approach for the identification of developmental toxicants. miRNAs represent a class of small regulatory RNA molecules, which bind to target mRNAs thereby repressing thei...
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-50216 | biostudies-arrayexpress
TranscriptomicsTranscriptomics changes in neural differentiated mouse embryonic stem cells (mESCs) under exposure to sodium valproate
Studying chemical disturbances during neural differentiation of mES cells has been established as an alternative in vitro testing approach for the identification of developmental toxicants. miRNAs represent a class of small regulatory RNA molecules, which bind to target mRNAs thereby repressing thei...
ORGANISM(S): Mus musculus 
2016-08-01 | E-GEOD-50215 | biostudies-arrayexpress
TranscriptomicsRNA-seq of isolated primary human CD8+ T cells treated with KDACi with polyclonal stimulation for 6 days
Lysine deacetylase inhibitors (KDACi) show immunomodulatory properties, promoting differentiation of an IL7RhiPD1lo memory precursor (MPEC) phenotype on polyclonal stimulation in vitro and enhancing functional memory responses during infection or immunisation in vivo. We isolated (MACS positive sele...
ORGANISM(S): Homo sapiens 
2024-09-01 | E-MTAB-13366 | biostudies-arrayexpress
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