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TranscriptomicsSubtype-specific genomic alterations define new targets for soft tissue sarcoma therapy
This SuperSeries is composed of the following subset Series: GSE21122: Whole-transcript expression data for soft-tissue sarcoma tumors and control normal fat specimens GSE21123: Affymetrix SNP array data for soft tissue sarcoma samples Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-07-05 | E-GEOD-21124 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for soft tissue sarcoma samples
Soft tissue sarcomas are aggressive mesenchymal cancers that affect more than 10,600 new patients per year in the US, about 40% of whom will die of their disease. Soft tissue sarcomas exhibit remarkable histologic diversity, with more than 50 recognized subtypes, but our knowledge of their genomic a...
ORGANISM(S): Homo sapiens 
2010-07-05 | E-GEOD-21123 | biostudies-arrayexpress
TranscriptomicsWhole-transcript expression data for soft-tissue sarcoma tumors and control normal fat specimens
Soft tissue sarcomas are aggressive mesenchymal cancers that affect more than 10,600 new patients per year in the US, about 40% of whom will die of their disease. Soft tissue sarcomas exhibit remarkable histologic diversity, with more than 50 recognized subtypes, but our knowledge of their genomic a...
ORGANISM(S): Homo sapiens 
2010-07-05 | E-GEOD-21122 | biostudies-arrayexpress
TranscriptomicsClear cell sarcoma human HEEBO microarray data
Clear cell sarcoma (CCS) of tendons and aponeuroses is a deadly soft-tissue malignancy resembling melanoma, with a predilection for young adults. EWS-ATF1, the fusion product of a balanced chromosomal translocation between chromosomes 22 and 12, is considered the definitional feature of the tumor. C...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-43045 | biostudies-arrayexpress
TranscriptomicsTrancription profiling of human soft tissue sarcomas: characterization & reclassification of malignant fibrous histiocytoma
In soft tissue sarcomas, diagnosis of malignant fibrous histiocytoma (MFH) has been a very controversial issue, and MFH is now considered to be reclassified into pleomorphic subtypes of other sarcomas. To characterize and reclassify MFH genetically, we analyzed gene expression in 105 samples from te...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-6481 | biostudies-arrayexpress
TranscriptomicsUndifferentiated Pleomorphic Sarcoma Model
Analysis of undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma-like tumors from LSL-KrasG12D, p53Fl/Fl mouse model of soft tissue sarcoma. Murine soft tissue sarcomas (n = 17) were compared to normal muscle (n = 4). Tumors were isolated surgically from soft tissue sarcomas generate...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-16779 | biostudies-arrayexpress
ProteomicsIlluminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics
Kinase inhibitors (KIs) are important cancer drugs but often display polypharmacology that is molecularly not understood. This disconnect is particularly apparent in cancer entities such as sarcomas for which the oncogenic drivers are often not clear. To investigate more systematically how the cellu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-11 | MSV000091043 | MassIVE
ProteomicsIlluminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics-2
Kinase inhibitors (KIs) are important cancer drugs but often display polypharmacology that is molecularly not understood. This disconnect is particularly apparent in cancer entities such as sarcomas for which the oncogenic drivers are often not clear. To investigate more systematically how the cellu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-29 | MSV000093533 | MassIVE
TranscriptomicsHypoxia and Intrinsic Transcriptomic Subtyping of Soft Tissue Sarcoma
The heterogeneity and multiple histological categories of soft tissue sarcoma (STS) underlie a need for better classification schemes to improve their management. As none are currently available, we aimed to derive hypoxia and intrinsic molecular subtype mRNA abundance signatures for localized soft ...
ORGANISM(S): Homo sapiens 
2017-11-17 | E-MTAB-6087 | biostudies-arrayexpress
TranscriptomicsShared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma of the extremities
Soft tissue sarcoma diagnostics and prognostics are challenging, particularly in highly malignant and pleomorphic subtypes such as undifferentiated pleomorphic sarcoma (UPS) and leiomyosarcoma (LMS). We applied 32K BAC-arrays and gene expression profiling to 18 extremity soft tissue LMS and 31 extre...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-13775 | biostudies-arrayexpress
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