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TranscriptomicsEnhancers of Polycomb 1 & 2 in normal and leukaemic haematopoiesis
A knockdown screen of chromatin regulatory genes in human THP1 MLL-AF9 AML cells identified EPC1 and EPC2 as required for cell survival. Normal myeloid progenitor cells did not require EPC1 or EPC2 for their function. To determine the transcriptional consequences of EPC knockdown, normal murine gran...
ORGANISM(S): Mus musculus 
2013-10-30 | E-GEOD-39172 | biostudies-arrayexpress
TranscriptomicsFrequent derepression of the mesenchymal transcription factor gene in acute myeloid leukemia (human)
Bone marrow samples from normal adult male donors were collected into EDTA. Red cells were removed by ammonium chloride lysis. Leukocytes were washed in SM buffer and CD34+ cells were separated from CD34- cells using an AutoMACS device and anti-CD34 immunomagnetic beads (Miltenyi Biotec), according ...
ORGANISM(S): Homo sapiens 
2015-09-17 | E-GEOD-66254 | biostudies-arrayexpress
TranscriptomicsFrequent derepression of the mesenchymal transcription factor gene in acute myeloid leukemia (mouse)
Murine CD45.1+ CD117+ BM cells were co-transduced pairwise with retroviral vectors expressing Hoxa9, Meis1, Foxc1 or a control empty vector. Ninety-six hours later 10^6 drug resistant cells were transplanted into CD45.2+ irradiated congenic recipients. To investigate the consequences of FOXC1 expres...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-66253 | biostudies-arrayexpress
TranscriptomicsFrequent derepression of the mesenchymal transcription factor gene in acute myeloid leukemia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-66256 | biostudies-arrayexpress
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