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TranscriptomicsEvaluation of transcriptomic profiles of peripheral blood myeloid cell subsets of RA patients in remission prior to cDMARD withdrawal, and at the point of flare / 6 months after in sustained remission
To test the contribution of distinct ST-DC populations to either autoimmunity and inflammation or sustained disease remission, we evaluated the phenotypes of their blood precursors in a human model of disease flare following treatment withdrawal in RA patients in disease remission (the BioRRA study,...
ORGANISM(S): Homo sapiens 
2024-12-09 | E-MTAB-14169 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-Seq of bovine macrophage cell lines from two cow strains infected with Theileria
To understand the immune response of cows to the apicomplexan parasite Theileria annulata, we used ex vivo isolate cells derived from two infected calve : Holstein 12886 (Bos taurus), which is known to be susceptible to the disease, and Sahiwal 82H (Bos indicus), which is known to be resistant. The ...
ORGANISM(S): Bos taurus 
2024-10-09 | E-MTAB-14450 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA and CITE sequencing of cells from synovial tissue biopsies of healthy donors, and Rheumatoid Arthritis (RA) patients with active disease or sustained clinical remission
The dataset includes the raw FASTQ files generated from the 10x Genomics Single Cell 3’ v3.1 experiments. For samples processed with TotalSeq Hashtag reagents, the corresponding hashtag oligonucleotide and condition annotations are provided as separate .csv files. The processed matrices contain filt...
ORGANISM(S): Homo sapiens 
2024-12-06 | E-MTAB-14213 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-Seq of IFN-γ stimulated murine bone marrow-derived macrophages (BMDMs) infected Toxoplasma
To study the effect of stress on macrophages due to Toxoplasma, we stimulated murine bone marrow-derived macrophages (BMDMs) with IFN-γ (no-stimulate control) and infected them with the apicomplexan parasite Toxoplasma gondii. scRNA-Seq (10X Chromium genomics ) was performed to understand the change...
ORGANISM(S): Mus musculus 
2024-10-09 | E-MTAB-14453 | biostudies-arrayexpress
TranscriptomicsCo-culture of synovial tissue dendritic cells with autologous peripheral blood memory T-Cells across Active and Remission RA
To dissect the precise roles of ST-DC2 clusters and ST-iDC3 clusters in T-cell activation, we co-cultured each cluster separately with autologous memory CD4pos T-cells. FACS-sorted ST-DC2 clusters and ST-iDC3 clusters from synovial tissue of active RA or remission RA were co-cultured for 5 days wit...
ORGANISM(S): Homo sapiens 
2024-12-09 | E-MTAB-14191 | biostudies-arrayexpress
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