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TranscriptomicsDeep transcriptome analysis of mouse embryonic fibroblast following simultaneous overexpression of Stella, Oct4 and Nanos2 (SON)
We constructed a polycistronic lentiviral vector to overexpress 3 germ cell specific genes (Stella, Oct4 and Nanos2) in mouse embryonic fibroblast (MEFs) and evaluated the transcriptome portrait in partially reprogrammed cells.We sequenced RNA samples from bulk cell population of two biological dup...
ORGANISM(S): Mus musculus 
2016-07-30 | E-GEOD-77351 | biostudies-arrayexpress
TranscriptomicsA comparison of physiological and transcriptome responses to water deprivation and salt loading in the rat supraoptic nucleus
Salt loading (SL) and water deprivation (WD) are experimental challenges that are often used to study the osmotic circuitry of the brain. Central to this circuit is the supraoptic nucleus (SON) of the hypothalamus, which is responsible for the biosynthesis of the hormones, vasopressin (AVP) and oxyt...
ORGANISM(S): Rattus norvegicus 
2015-02-05 | E-GEOD-65663 | biostudies-arrayexpress
TranscriptomicsSon Maintains Accurate Splicing of Pre-mRNAs Encoding Chromatin Modifiers
Exon and expression analysis of HeLa cells after knockdown of SON Serine-arginine-rich (SR) proteins play a key role in alternative pre-mRNA splicing in eukaryotes. Our laboratory recently showed that a large SR protein called Son has unique repeat motifs that are essential for maintaining the subnu...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-28672 | biostudies-arrayexpress
TranscriptomicsExpression data from HeLa cells transiently transfected with control siRNA or SON siRNA
SON is a large Ser/Arg (SR)-related protein localized in nuclear speckles. SON siRNA causes defects in mitotic progression and genome instability. We used microarrays to detail the pattern of gene expression after SON knockdown. HeLa cells were grown in 100 mm dishes and transfected with negative co...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-26888 | biostudies-arrayexpress
TranscriptomicsHypothalamic transcriptome plasticity in two rodent species reveals divergent differential gene expression but conserved pathways
We have addressed the question of how different rodent species cope with the life-threatening homeostatic challenge of dehydration at the level of transcriptome modulation in the supraoptic nucleus (SON), a specialised hypothalamic neurosecretory apparatus responsible for the production of the antid...
ORGANISM(S): Mus musculus 
2010-11-29 | E-GEOD-25574 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat hypothalamo-neurohypophyseal system reveals gene expression is highly strain-dependant
We have used microarrays to comprehensively describe the transcriptomes of the supraoptic nucleus (SON), the paraventricular nucleus (PVN) and the neurointermediate lobe (NIL) of adult male Sprague-Dawley (SD) and Wistar-Kyoto (WKY) rats, as well as the paraventricular nucleus of Wistar (WIST) rats....
ORGANISM(S): Rattus norvegicus 
2008-10-25 | E-GEOD-8491 | biostudies-arrayexpress
UnknownDe Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome.
Not available
S-EPMC5011044 | biostudies-literature
TranscriptomicsGene expression profiling of high (HAB) vs. low (LAB) anxiety-related behavior mice in seven brain regions.
Investigating the molecular basis and correlates of anxiety-related and depression-like behaviors, we generated a mouse model consisting of high (HAB) and low (LAB) anxiety-related behavior mice. We utilized the elevated plus-maze for testing the genetic predisposition to anxiety-related behavior an...
ORGANISM(S): Mus musculus 
2011-08-29 | E-GEOD-28999 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of the osmotic and reproductive remodelling of the female rat supraoptic nucleus
The supraoptic nucleus (SON) of the hypothalamus is an important integrative brain structure that co-ordinates responses to perturbations in water balance and regulates maternal physiology through the release of the neuropeptide hormones vasopressin and oxytocin into the circulation. Both dehydratio...
ORGANISM(S): Rattus norvegicus 
2011-12-29 | E-GEOD-30733 | biostudies-arrayexpress
TranscriptomicsmTAIL-seq reveals dynamic poly(A) tail regulation in oocyte-to-embryo development
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2016-08-01 | E-GEOD-83732 | biostudies-arrayexpress
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