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TranscriptomicsTranscription profiling by high throughput sequencing of MPN1 deficient human cells
Clericuzio-type poikiloderma with neutropenia (PN, Mendelian Inheritance in Man (MIM) accession 604173) is a rare genodermatosis associated to mutations in the MPN1 gene. The aim of this experiment was to investigate the the effect of MPN1 mutations on pre-mRNA transcripts maturation. We compared th...
ORGANISM(S): Homo sapiens 
2012-07-27 | E-MTAB-1197 | biostudies-arrayexpress
TranscriptomicsIllumina RNA-seq of polyA+ RNA from HAP1 cells
Illumina RNA-seq was performed on polyA+ RNA isolated from the human HAP1 cell line
ORGANISM(S): Homo sapiens 
2019-03-14 | E-MTAB-7757 | biostudies-arrayexpress
TranscriptomicsRNA-seq of two human mammary epithelial cell lines (HMLE and HMLE-Twist-ER) treated with 4-hydroxytamoxifen vs control
Immortalized non-cancerous human mammary epithelial cells (HMLE) were transfected to express the murine fusion protein Twist1-estrogen receptor(point mutation G525R) (HTER). Twist1-mediated gene expression is activated by stimulation with 4-hydroxytamoxifen for several days and induces an epithelial...
ORGANISM(S): Homo sapiens 
2021-03-24 | E-MTAB-9365 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of endometrial organoids in the IVMC protocol
Accessing endometrial tissue during the early phases of the menstrual cycle is challenging. With this experiment we are capturing the dynamic epithelial cell states after breakdown using endometrial organoids (EOs) subjected to the in vitro menstrual cycle (IVMC) protocol. EOs are collected for scRN...
ORGANISM(S): Homo sapiens 
2026-04-28 | E-MTAB-15330 | biostudies-arrayexpress
TranscriptomicsRNA-seq of HEK293T total RNA treated with 40 nM pre-miR-124/pre-miR-132 against mock treated control samples
The expression of different RNAs in miR-124/miR-132 transfected HEK293T cells were compared to mock treated samples in order to describe fold change of transcripts assigned as miRNA targets by different tools or experiments.
ORGANISM(S): Homo sapiens 
2020-11-23 | E-MTAB-8516 | biostudies-arrayexpress
Transcriptomicshuman 3' RACE
Mpn1 proteins are evolutionarily conserved exonucleases that modify spliceosomal U6 small nuclear RNAs (snRNAs) post-transcriptionally. Mutations in the human MPN1 gene are associated to the genodermatosis Clericuzio-type poikiloderma with neutropenia (PN). Mpn1 deficiency leads to aberrant U6 3M-bM...
ORGANISM(S): Homo sapiens 
2014-08-08 | E-GEOD-60196 | biostudies-arrayexpress
Transcriptomicsyeast U6 3' RACE
Mpn1 proteins are evolutionarily conserved exonucleases that modify spliceosomal U6 small nuclear RNAs (snRNAs) post-transcriptionally. Mutations in the human MPN1 gene are associated to the genodermatosis Clericuzio-type poikiloderma with neutropenia (PN). Mpn1 deficiency leads to aberrant U6 3M-bM...
ORGANISM(S): Schizosaccharomyces pombe 
2014-08-08 | E-GEOD-60195 | biostudies-arrayexpress
TranscriptomicsGlobal 3' RACE in yeast and humans
Mpn1 proteins are evolutionarily conserved exonucleases that modify spliceosomal U6 small nuclear RNAs (snRNAs) post-transcriptionally. Mutations in the human MPN1 gene are associated to the genodermatosis Clericuzio-type poikiloderma with neutropenia (PN). Mpn1 deficiency leads to aberrant U6 3M-bM...
ORGANISM(S): Homo sapiens 
2014-08-08 | E-GEOD-60197 | biostudies-arrayexpress
TranscriptomicsRNA-seq of miR-CLIP double purified, miR-124/miR-132 miR-CLIP probe treated HEK293T cells and corresponding mock treated and intermediate samples
Targetome of miR-124/miR-132 was enriched in HEK293T cells, a cell line which lacks the expression of these miRNA. The targetome was captured using miR-CLIP, a transfection-based double-purification crosslinking and immunoprecipitation (CLIP) method. Therefore HEK293T cells were transfected with miR...
ORGANISM(S): Homo sapiens 
2020-11-23 | E-MTAB-8517 | biostudies-arrayexpress
TranscriptomicsRNA-seq of one human cortex sample and one sample from the HAP1 cell line, used to illustrate the development and application of the JCC score
Two RNA-seq libraries were used as example data to illustrate the development and application of the junction coverage compatibility (JCC) score. They represent different experimental systems and were sequenced on different hardware on different occasions, which was desirable in order to illustrate ...
ORGANISM(S): Homo sapiens 
2018-08-06 | E-MTAB-7089 | biostudies-arrayexpress
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