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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
UnknownTargeting piRNA-137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via De Novo Cholesterol Biosynthesis in Lung Adenocarcinoma.
Not available
S-EPMC11809383 | biostudies-literature
ProteomicsMass spectrometry analysis of proteins interacting with cGAS
o identify the potential associated proteins of cGAS, we performed co-IP followed by mass spectrometry analysis in HEK293A cells stably expressing SFB-tagged cGAS.
ORGANISM(S): Homo sapiens (Human) 
2022-02-07 | PXD023597 | Pride
Lc-ms/ms Hek293a Cgas 
ProteomicsIdentification of the Kinase phosphorylation sites on AtGPA1 in presence of GDP
Phosphorylation of GPA1 has been shown to functionally important in vitro and in vivo. We previously identified18 LRR RLKs transphosphorylation of AtGPA1 via in vitro kinase assay using recombinant kinase domains and AtGPA1 (Bo et al., 2018, J. Biol. Chem 293(13): 4752-4766). Among them, we here cho...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2019-06-12 | MSV000083963 | MassIVE
MetabolomicsInsulin Resistance-Associated Bifidobacterium longum Ameliorates Prediabetes via the 6-ketoLCA/TGR5/GLP-1 axis

Background Prediabetes, a global health concern characterized by insulin resistance (IR) and closely linked to obesity, was investigated in this study to identify key gut microbiota characteristics. The development of insulin resistance is associated with gut microbiota. Therefore, identifying ke...

2026-01-14 | MTBLS13684 | MetaboLights
ProteomicsIdentification of the Kinase phosphorylation sites on AtGPA1 in presence of GTP
Phosphorylation of GPA1 has been shown to functionally important in vitro and in vivo. We previously identified18 LRR RLKs transphosphorylation of AtGPA1 via in vitro kinase assay using recombinant kinase domains and AtGPA1 (Bo et al., J Biol Chem 293(13): 4752-4766). Among them, we choose 12 kinase...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2019-06-12 | MSV000083964 | MassIVE
UnknownSafety and feasibility of laparoscopic surgery for colorectal and gastric cancer under the Chinese multi-site practice policy: admittance standards of competence are needed.
Not available
S-EPMC9522381 | biostudies-literature
UnknownFusobacterium nucleatum upregulates MMP7 to promote metastasis-related characteristics of colorectal cancer cell via activating MAPK(JNK)-AP1 axis.
Not available
S-EPMC10561506 | biostudies-literature
ProteomicsLiP-small molecule mapping of Farrerol
Limited proteolysis combined with mass spectrometry of farrerol treated. Briefly, cell lysates containing approximately 500 μg of total protein sample were incubated with farrerol or vehicle (DMSO) for 10 min at 25 °C. Proteinase K (5 μg, Sigma–Aldrich) was added simultaneously to each sample for t...
ORGANISM(S): Homo Sapiens 
2022-08-25 | PXD036308 |
UnknownA single-cell atlas of bladder cancer unveils dynamic cellular composition and endothelial functional shifts during progression.
Not available
S-EPMC11982012 | biostudies-literature
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