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ProteomicsIdentification of cGAS acetylation and phosphorylation
DNA derived from the genetic material of pathogens or from cellular DNA damage provides a molecular pattern that can be sensed by pattern-recognition receptors of the mammalian innate immune system. In recent years, the cyclic GMP-AMP synthase (cGAS) protein has been characterized as a primary cytos...
ORGANISM(S): Homo sapiens (Human) 
2020-05-11 | PXD017109 | Pride
Human Herpesvirus Affinity purification Ptm Immune response 
ProteomicsInteraction proteins of cGAS and PSMA4 with lactate treatment
Sample 1: Control Sample 2: Interaction proteins of Flag-cGAS Sample 3: Interaction proteins of Flag-cGAS with lactate treatment Sample 4: Interaction proteins of Flag-PSMA4 Sample 5: Interaction proteins of Flag-PSMA4 with lactate treatment
ORGANISM(S): Homo sapiens (Human) 
2025-03-21 | PXD053886 | Pride
Lactate Psma4 Cgas 
ProteomicscGAS Senses Translation Stress Through Direct Binding to Ribosomes
The cGAS-STING pathway, a central component of the innate immune system, senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to mediate inflammation. Here we report the unexpected discovery that cGAS senses dysfunctional protein production. Purified ribosomes interact with and stimul...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019359 | Pride
Ribosomes Ascc Human Cgas 
TranscriptomicsGene induction in STAT1-/- fibroblasts transduced with lentiviruses expressing human cGAS
The hypothesis tested was that lentiviral driven cGAS expression activates antiviral gene expression. Cells were transduced with lentiviruses expressing cGAS or a control (firefly luciferase). Total RNA was harvested 48 h post-transduction and processed for Illumina BeadArray.
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-52241 | biostudies-arrayexpress
ProteomicsMass spectrometry analysis of proteins interacting with cGAS
o identify the potential associated proteins of cGAS, we performed co-IP followed by mass spectrometry analysis in HEK293A cells stably expressing SFB-tagged cGAS.
ORGANISM(S): Homo sapiens (Human) 
2022-02-07 | PXD023597 | Pride
Lc-ms/ms Hek293a Cgas 
ProteomicsmTORC2-driven chromatin cGAS mediates chemoresistance in colorectal cancer
Cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor that initiates a STING-dependent innate immune response, binds tightly to chromatin, where its catalytic activity is inhibited. However, the mechanisms underlying cGAS recruitment to chromatin and the functions of chromatin-bound cGAS (ccGAS) re...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053068 | Pride
Mtorc2 Chromatin cgas Phosphorylation Kga Chemoresistance 
ProteomicsHuman SUM159 cell LC-MSMS to identify the kinase that phosphorylates cGAS
Mutation analysis suggested that phosphorylation of cGAS at serine 120 is responsible for nuclear retention of cGAS by combining nucleoplasmic separation assay with immunofluorescence assay. Then, we sought to identify the kinase that phosphorylates cGAS.
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD052380 | Pride
Human Cgas Sum159 
ProteomicsHuman SUM159 cell LC-MS/MS to identify proteins that interact with cGAS
To investigate the potential mechanisms underlying the effects of cGAS on TNBC metastasis, we performed LC-MS/MS analysis.
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD052823 | Pride
Human Cgas Interaction Sum159 
ProteomicsNeddylation modification on cGAS of human and mouse
The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) has emerged as a fundamental component fueling the anti-pathogen immunity. Because of its pivotal role in initiating innate immune response, the activity of cGAS must be tightly fine-tuned to maintain immune homeostasis in antiviral r...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-02-22 | PXD024088 | Pride
Human Cgas Neddylation Mouse 
ProteomicsProximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
Cyclic GMP-AMP synthase (cGAS), as the major DNA sensor, initiates DNA-stimulated innate immune responses and is essential for healthy immune system. Although some regulators of cGAS have been reported, it still remains largely unknown about how cGAS is precisely and dynamically regulated and how ma...
ORGANISM(S): Homo Sapiens 
2023-03-02 | PXD040544 |
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