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ProteomicsNeddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed developmentally down-regulated protein 8, to target proteins, with yet-unknown consequences. Here we show in mice that neddylation in liver is modulated by nutrient availability. ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-08 | PXD043054 | Pride
Pck1 Neddylation Glucose 
ProteomicsNeddylation modification on cGAS of human and mouse
The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) has emerged as a fundamental component fueling the anti-pathogen immunity. Because of its pivotal role in initiating innate immune response, the activity of cGAS must be tightly fine-tuned to maintain immune homeostasis in antiviral r...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-02-22 | PXD024088 | Pride
Human Cgas Neddylation Mouse 
ProteomicsExploration of GFP-IRF7 neddylation sites
To explore the possible neddylation sites, GFP-IRF7 and His-NEDD8 were co-overexpressed in HEK293 cell line and GFP was immunoprecipitated, followed by SDS-PAGE and silver staining. The band detected was subjected to LC–MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2021-08-19 | PXD024052 | Pride
Hek293 Gfp-irf7 Lc-ms/ms 
ProteomicsPevonedistat inhibits aberrant protein NEDDylation in Polycystic Liver Diseases.
Background: Polycystic liver diseases (PLD) are genetic disorders characterized by progressive growth of numerous liver cysts, causing significant morbidity. Previous studies revealed genes affecting protein biogenesis and more recently, protein SUMOylation, a posttranslational modification (PTM), h...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD022571 | Pride
Hepatic cystogenesis  mln4924  pevonedistat  neddylation  therapy  nae1. 
ProteomicsNEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
SILAC quantitative mass spectrometry analysis on protein aggregates induced upon heat shock. Two separate performed analysis: A) control siRNA cells (light) with siRNA NEDD8 cells (heavy) and B) control cells (light) with MLN4924 treated cells (heavy). In all conditions cells were heat shocked at 43...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-17 | MSV000082623 | MassIVE
ProteomicsNeddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients
The COVID-19 pandemic caused by SARS-CoV-2 has reached 5.5 million deaths worldwide, causing a huge impact globally. This highly contagious viral infection produces a severe acute respiratory syndrome that includes cough, mucus, fever and pneumonia. Likewise, many hospitalized patients develop sever...
ORGANISM(S): Homo sapiens (Human) 
2022-08-02 | PXD033673 | Pride
Pbmc Neddylation Coid-19 
ProteomicsNeddylation inhibition halts acetaminophen induced liver injury boosting anabolic cardiolipin pathway
Drug Induced-liver injury (DILI) is a significant cause of acute liver failure (ALF) and liver transplantation in the Western world. APAP overdose is a main contributor of DILI, leading to hepatocyte cell death through necrosis. Herein, we identified that neddylation, an essential post-translational...
ORGANISM(S): Mus Musculus 
PXD053221 |
ProteomicsSENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin- 1 RING ubiquitin ligase function
NEDD8 is a ubiquitin-like modifier most well-studied for its role in activating the largest family of ubiquitin E3 ligases, the cullin-RING ligases (CRLs). While many non-cullin neddylation substrates have been proposed over the years, validation of true NEDD8 targets has been challenging, as overex...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-13 | MSV000080917 | MassIVE
ProteomicsTargeting neddylation is a novel therapeutic strategy for lupus by reconstructing double negative T cell homeostasis
Systemic lupus erythematosus (SLE) is an autoimmune disorder with systemic inflammation, autoantibody accumulation and organ damage. The abnormalities of double-negative (DN) T cells are considered as an important commander of SLE. Neddylation, an important type of protein post-translational modific...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD045686 | Pride
Neddylation  ube2m  systemic lupus erythematosus (sle)  bim  double negative t cells (dn t cells)  apoptosis 
GenomicsSAG/Rbx2-Dependent Neddylation Regulates T-cell Responses
SAG/Rbx2-Dependent Neddylation Regulates T-cell Responses
PRJNA622260 | ENA
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