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MetabolomicsUntargeted metabolomics profiling of intestinal epithelium-specific PCK1 knockout mice and littermate controls

Metabolic dysregulation may serve as a pivotal driver of inflammatory bowel disease, with the crosstalk between metabolism and the immune system emerging as a critical research focus. Ulcerative colitis patients exhibit enhanced glycolysis but suppressed ...

2026-06-24 | MTBLS12440 | MetaboLights
MetabolomicsGluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and H3K9me3 to suppress HCC progression
Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic enzyme PCK1 fuels the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. The methyltransfera...
2025-08-09 | MTBLS7651 | MetaboLights
ProteomicsPCK1 acetylation reactivity - stoichiometry
Site-specific reactivity of PCK1 to increasing concentrations of acetyl-CoA. Acetylation stoichiometry is calculated and second-order rate constants are derived.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
MSV000086210 | MassIVE
GenomicsRenal tubular Pck1 knockout mice showed albuminuria.
Renal tubular Pck1 knockout mice showed albuminuria.
PRJNA947941 | ENA
GenomicsRRBS of PCK1 knockout in PLC/PRF/5
RRBS of PCK1 knockout in PLC/PRF/5
PRJNA915616 | ENA
GenomicsSHP-1 regulates transcription of PCK1 to control gluconeogenesis
SHP-1 regulates transcription of PCK1 to control gluconeogenesis
PRJNA728582 | ENA
ProteomicsNeddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed developmentally down-regulated protein 8, to target proteins, with yet-unknown consequences. Here we show in mice that neddylation in liver is modulated by nutrient availability. ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-08 | PXD043054 | Pride
Pck1 Neddylation Glucose 
GenomicsPCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8+ T cell dysfunction
PCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8+ T cell dysfunction
PRJNA1292780 | ENA
TranscriptomicsRenal tubular Pck1 knockout mice showed albuminuria.
We aim to investigate the role of renal Pck1 on albuminuria. To further development of our gene expression approach to biodosimetry, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish between wild type mice. To el...
ORGANISM(S): Mus musculus 
2023-03-29 | GSE228053 | GEO
ProteomicsImmunoprecipitation of cGAS/PCK1 and mass spectrometry analysis
BT-549 cells (5× 10^7) were treated with hypoxia treatment for 2 h. An immunoprecipitation assay was performed using anti-cGAS or anti-PCK1 antibody, and immunoprecipitates of cGAS or PCK1 were separated using SDS-PAGE and stained with Coomassie Brilliant Blue. Selected peptide hits of proteins asso...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD057891 | Pride
Human tnbc lc-msms 
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