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ProteomicsMiRNA-378a-5p attenuates the development of abdominal aortic aneurysm via ABLIM1-MKL1 signaling pathways
Abstract Objectives: Abdominal aortic aneurysm (AAA) is a fatal cardiovascular disease with no effective drug treatment currently available. The aberrant expressions of microRNAs (miRNAs) contribute to AAA pathogenesis. In this study, we aimed to perform miRNA microarray analysis to screen for diffe...
ORGANISM(S): Homo Sapiens 
2026-01-13 | PXD073033 |
ProteomicsTransgenic mice with myeloid-specific overexpression of human S100A12
S100A12, a newly discovered member of the S100 family of calcium regulatory proteins, is located within the same gene cluster on chromosome 1q21 as other S100A family members. In humans, S100A12 is mainly secreted by neutrophils and monocytes, but can also be expressed by tissue cells, such as mucos...
ORGANISM(S): Mus <genus> 
2025-01-25 | PXD060232 |
ProteomicsProteomic Insights into Aprotinin’s Immunomodulatory Effects in Attenuating Renal Fibrosis in a Unilateral Ureteral Obstruction Model
Chronic kidney disease (CKD) is characterized by progressive renal fibrosis and immune dysregulation. Aprotinin, a broad-spectrum serine protease inhibitor, has shown dose-dependent effects on kidney function, but its role in chronic obstructive nephropathy remains unclear.
ORGANISM(S): Mus Musculus 
2025-05-03 | PXD063655 |
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