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TranscriptomicsTranscription profiling of acute monocytic leukemia (AML-M5) patients with DNMT3A mutations
To understand the pathogenesis of DNMT3A in acute monocytic leukemia (AML-M5), we identified genes that are expressed differently in leukemia cells from AML-M5 patients collected at diagnosis with DNMT3A mutations (6 cases) compared to those without the mutations (4 cases). Differences of expression...
ORGANISM(S): Homo sapiens 
2011-02-12 | E-GEOD-27187 | biostudies-arrayexpress
TranscriptomicsNormalization of whole-genome SNP data from acute monocytic leukemia patients for exome sequencing
With the whole genome SNPs array information, we could evaluate the sensitivity and specificity of the point mutation we conclude from the next-generation sequencing data. Furthermore, we could use the true positive mutation as our guidance to exclude the most unreliable single nucleotide variation...
ORGANISM(S): Homo sapiens 
2011-02-12 | E-GEOD-27193 | biostudies-arrayexpress
ProteomicsIntegrated multi-omics analysis of zinc deficiency
Zinc is an essential trace micronutrient and exerts important physiological and biochemical roles. Zinc deficiency is a global public-health problem. Standing untreated zinc deficiency can cause series adverse effects, including growth retardation, poor appetite, delayed sexual development, impaired...
ORGANISM(S): Rattus Norvegicus 
2019-06-05 | PXD014079 |
ProteomicsHippocampal proteomics analysis of marginal zinc deficiency
Zinc is an essential trace element that is closely related to learning and memory ability. The hippocampus plays an important role in learning and memory and has the highest zinc concentration in the brain. Severe zinc deficiency (zinc-deprived diet) significantly alter hippocampal protein expressio...
ORGANISM(S): Rattus Norvegicus 
2021-10-04 | PXD028998 |
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