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MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
TranscriptomicsCirculating insulin-like growth factor (IGF)-1 Regulates Hippocampal IGF-1 Levels and Brain Gene Expression During Adolescence
This study, using a growth hormone (GH)-deficient dwarf animal model and peripheral GH replacement, investigated the effects of circulating IGF-1 during adolescence on IGF-1 levels in the brain. Our results demonstrated that hippocampal IGF-1 protein concentrations during adolescence are highly regu...
ORGANISM(S): Rattus norvegicus 
2011-07-20 | E-GEOD-29512 | biostudies-arrayexpress
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
UnknownSystemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells.
Not available
S-EPMC4166745 | biostudies-literature
UnknownBloch Surface Waves Biosensors for High Sensitivity Detection of Soluble ERBB2 in a Complex Biological Environment.
Not available
S-EPMC5618039 | biostudies-literature
UnknownNew lineage of scuticociliates dominates the ciliate community and bacterivory in hypolimnetic waters of a freshwater reservoir.
Not available
S-EPMC12366787 | biostudies-literature
UnknownNovel Technique for C1-2 Interlaminar Arthrodesis Utilizing a Modified Sonntag Loop-Suture Graft With Posterior C1-2 Fixation.
Not available
S-EPMC7538353 | biostudies-literature
ModelsSonntag2012 - mTOR model - IRS dependent regulation of AMPK by insulin
Sonntag2012 - mTOR model - IRS dependent regulation of AMPK by insulin TSC1-TSC2 complex has two states: 1) active (TSC1_TSC2_pS1387), regulated by AMPK_pT172; 2) inactive (TSC1_TSC2_pT1462) regulated by Akt_pT308. Particularly, mTORC1 is inhibited by TSC1_TSC2 in active state. AMPK is activated at ...
2024-09-02 | BIOMD0000000580 | BioModels
UnknownThe potential underlying mechanisms during learning flights.
Not available
S-EPMC10354122 | biostudies-literature
UnknownLake Ecosystem Robustness and Resilience Inferred from a Climate-Stressed Protistan Plankton Network.
Not available
S-EPMC8001626 | biostudies-literature
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