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UnknownEffect of Patient Navigation With or Without Financial Incentives on Viral Suppression Among Hospitalized Patients With HIV Infection and Substance Use: A Randomized Clinical Trial.

Importance

Substance use is a major driver of the HIV epidemic and is associated with poor HIV care outcomes. Patient navigation (care coordination with case management) and the use of financial incentives for achieving predetermined outcomes are interventions increasingly promoted to engage...
S-EPMC5339876 | biostudies-literature
UnknownPolygenic hazard score is associated with prostate cancer in multi-ethnic populations.
Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance ...
S-EPMC7902617 | biostudies-literature
UnknownAssessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study.

Background

Epigenetic clocks have been associated with cancer risk in several observational studies. Nevertheless, it is unclear whether they play a causal role in cancer risk or if they act as a non-causal biomarker.

Methods

We conducted a two-sample Mendelian randomization (MR) stud...
S-EPMC9049976 | biostudies-literature
UnknownAdditional SNPs improve risk stratification of a polygenic hazard score for prostate cancer.

Background

Polygenic hazard scores (PHS) can identify individuals with increased risk of prostate cancer. We estimated the benefit of additional SNPs on performance of a previously validated PHS (PHS46).

Materials and method

180 SNPs, shown to be previously associated with prostate ca...
S-EPMC8157993 | biostudies-literature
UnknownProstate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score.

Background

Prostate cancer risk stratification using single-nucleotide polymorphisms (SNPs) demonstrates considerable promise in men of European, Asian, and African genetic ancestries, but there is still need for increased accuracy. We evaluated whether including additional SNPs in a prostat...
S-EPMC9372232 | biostudies-literature
UnknownThe <i>CHEK2</i> Variant C.349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor.
The identification of recurrent founder variants in cancer predisposing genes may have important implications for implementing cost-effective targeted genetic screening strategies. In this study, we evaluated the prevalence and relative risk of the CHEK2 recurrent variant c.349A>G in a series...
S-EPMC7694218 | biostudies-literature
UnknownCirculating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.

Background

Whether associations between circulating metabolites and prostate cancer are causal is unknown. We report on the largest study of metabolites and prostate cancer (2,291 cases and 2,661 controls) and appraise causality for a subset of the prostate cancer-metabolite associations usi...
S-EPMC6746173 | biostudies-literature
UnknownRisk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.

Background

Genome-wide association studies have identified multiple genetic variants associated with prostate cancer risk which explain a substantial proportion of familial relative risk. These variants can be used to stratify individuals by their risk of prostate cancer.

Methods

We g...
S-EPMC4491026 | biostudies-literature
UnknownLarge-scale transcriptome-wide association study identifies new prostate cancer risk regions.
Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely unknown. Here we integrate the largest PrCa GWAS (N = 142,392) with gene expression measured in 45 tissues (N = 4458), includi...
S-EPMC6172280 | biostudies-literature
UnknownSeven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage...
S-EPMC3396006 | biostudies-literature
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