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ProteomicsIdentification of SORL1 Binding Partners via Immunoprecipitation-Mass Spectrometry in THP-1 Cells.
SORL1 (Sortilin-Related Receptor 1) is a key player in endosomal trafficking and has been implicated in neurodegenerative disorders. To identify SORL1 binding partners, we performed immunoprecipitation (IP) of SORL1, followed by mass spectrometry-based proteomic analysis. THP-1 cell lysates were use...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD061057 | Pride
Alzheimer’s disease Protein-protein interaction Sorl1 Microglia Genetics 
ProteomicsSORL1 regulates APOE and CLU levels in human neurons
SORL1 is implicated in the pathogenesis of Alzheimer’s disease (AD) through genetic studies. To interrogate the role(s) of SORL1 in human brain cells, SORL1 null iPSCs are differentiated to neuron, astrocyte, microglial, and endothelial cell fates. Loss of SORL1 leads to alterations in both overlapp...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD044093 | Pride
Lc-ms/ms Alzheimer's Tmt 
ProteomicsFamilial Alzheimer disease mutation in SORL1 impairs release of neurotrophic extracellular vesicles by microglia
Coding mutations in SORL1, the gene encoding sortilin-related receptor with A-type repeats (SORLA) are common in individuals suffering from Alzheimer’s disease (AD) of unknown etiology. These findings suggest SORL1 as a novel familial disease gene causative of AD. SORL1 mutations characterized so fa...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD061828 | Pride
Alzheimer’s disease Extracellular vesicles Sorl1 
GenomicsEffect of interferon gamma on wild type and SORL1 knockout iPSC-derived microglia
Effect of interferon gamma on wild type and SORL1 knockout iPSC-derived microglia
PRJNA1224834 | ENA
GenomicsThe Alzheimer’s gene SORL1 is a key regulator of endosomal recycling in human neurons
The Alzheimer’s gene SORL1 is a key regulator of endosomal recycling in human neurons
PRJNA749578 | ENA
GenomicsSORL1 is a mediator of KRAS driven oncogenesis in multiple myeloma
SORL1 is a mediator of KRAS driven oncogenesis in multiple myeloma
PRJNA1394780 | ENA
UnknownExpression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain.
Not available
S-EPMC2776013 | biostudies-literature
UnknownThe Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression.
Not available
S-EPMC3117021 | biostudies-literature
TranscriptomicsThe Alzheimer’s gene SORL1 is a key regulator of endosomal recycling in human neurons
Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a causal event for Alzheimer’s disease (AD). Recent studies have established that loss of SORL1, as well as mutations in autosomal dominant AD genes APP and PSEN1/2, pathogenically converge by swelling early endosomes, AD’s cytopat...
ORGANISM(S): Homo sapiens 
2022-03-01 | GSE180793 | GEO
TranscriptomicsCell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1
SORL1 is strongly implicated in the pathogenesis of Alzheimer’s disease (AD) through human genetic studies that point to an association of reduced SORL1 levels with higher risk for AD. To interrogate the role(s) of SORL1 in human brain cells, SORL1 null iPSCs were generated, followed by differentiat...
ORGANISM(S): Homo sapiens 
2023-07-24 | GSE238013 | GEO
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