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TranscriptomicsDistinct structural transitions of chromatin topological domains coordinate hormone-induced gene regulation
The three-dimensional (3D) organization of the genome within the cell nucleus contributes to cell-specific gene expression in different cell types1. High-throughput 3CM-bM-^@M-^Sderived methods have revealed that the genome is segmented into contiguous topologically associating domains (TADs), which...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-53463 | biostudies-arrayexpress
GenomicsCDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells.
Eukaryotic gene regulation implies that transcription factors gain access to genomic information via poorly understood processes involving activation and targeting of kinases, histone-modifying enzymes, and chromatin remodelers to chromatin. Here we report that progestin gene regulation in breast ca...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-53855 | biostudies-arrayexpress
GenomicsNucleosome driven transcription factor binding and gene regulation [ChIP-Seq]
Elucidating the global function of a transcription factor implies the identification of its target genes and genomic binding sites. The role of chromatin in this context is unclear, but the dominant view is that factors bind preferentially to nucleosome-depleted regions, identified as DNaseI-hyperse...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-41466 | biostudies-arrayexpress
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