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Transcriptomicsrat small intestine samples
Experiment description 1. Experimental design 1) Authors, laboratory, and contact: Xue-Lin Cui1, Patricia Soteropoulos2, Peter Tolias2, Ronaldo P. Ferraris1: 1Dept. of Pharmacology and Physiology, UMDNJ-New Jersey Medical School, Newark, NJ 07103-2714, 2Center for Applied Genomics, PHRI, 225 Warre...
ORGANISM(S): Rattus norvegicus 
2010-06-09 | E-GEOD-996 | biostudies-arrayexpress
TranscriptomicsThe global transcriptional profile of Mycobacterium tuberculosis during human macrophages infection
During lung infection Mycobacterium tuberculosis (Mtb) resides in macrophages and subverts the bactericidal mechanisms of these professional phagocytes. In this work we have analyzed by DNA microarray technique the global transcription profile of Mtb infecting primary human macrophages in order to i...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-27 | E-GEOD-6209 | biostudies-arrayexpress
TranscriptomicsS_aureus_&_triclosan
A triclosan-ciprofloxacin cross-resistant mutant strain of Staphylococcus aureus displays an alteration in the expression of several cell membrane structural and functional genes. Triclosan is an antimicrobial agent found in many consumer products. Several studies have demonstrated that triclosan ...
ORGANISM(S): Staphylococcus aureus 
2010-05-26 | E-GEOD-5799 | biostudies-arrayexpress
TranscriptomicsSigma factor E of Mycobacterium tuberculosis controls the expression of bacterial components that modulate macrophages
Sigma factor E (SigE) controls the expression of genes that are essential for Mtb virulence. In this work, we have identified the SigE regulon during infection of macrophages Our results indicate that SigE regulates the expression of genes involved in the maintenance of Mtb cell envelope integrity a...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-7962 | biostudies-arrayexpress
TranscriptomicsTranscritpome analysis of Mycobacterium tuberculosis (Mtb) mutants deficient in ergothioneine, or mycothiol production
This experiment was performed to determine deferentially regulated genes in the absence of redox buffer ergothioneine (EGT), or mycothiol (MSH). We had used two Mtb mutants namely egtA:Tn and egtD:Tn which are deficient in EGT production ( Transposon Mutant of EGT biosynthesis pathway); In additi...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2016-01-27 | E-MTAB-4099 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human oral sqamous cell carcinoma patients vs normal samples to associate gene expression profiles and tumor invasion
There are limited studies attempting to correlate the expression changes in oral squamous cell carcinoma with clinically relevant variables. We determined the gene expression profile of 16 tumor and 4 normal tissues from 16 patients by means of Affymetrix Hu133A GeneChips. The hybridized RNA was iso...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-3524 | biostudies-arrayexpress
TranscriptomicsProfiling and Functional Analyses of MicroRNAs and Their Target Gene Products in Human Uterine Leiomyomas
Human uterine leiomyomas (ULM) are characterized by dysregulation of a large number of genes and non-coding regulatory microRNAs. In order to identify microRNA::mRNA associations relevant to ULM pathogenesis, we examined global correlation patterns between the altered microRNA expression and the pre...
ORGANISM(S): Homo sapiens 
2010-07-24 | E-GEOD-23112 | biostudies-arrayexpress
TranscriptomicsIntracellular expression pattern of recombinant Mtb strain TB294 overexpressing sigma factor A
We previously showed that increased expression of the principal sigma factor, SigA, mediates the capacity of Mycobacterium tuberculosis 210 strains to grow more rapidly in human monocytes, compared to other strains. To identify SigA-regulated genes that favor intracellular mycobacterial growth, we u...
ORGANISM(S): Mycobacterium tuberculosis 
2010-10-08 | E-GEOD-13780 | biostudies-arrayexpress
TranscriptomicsGene Expression Across the Human Growth Plate
Chondrocytes advance through the long bone growth plate in synchrony, allowing their segregation into one of four zones each corresponding to a different phase of maturation. Beginning from the epiphysis the recognized zones are: reserve, proliferative, prehypertrophic, and hypertrophic. A fifth zon...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-9160 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lens epithelial cells to examine glucocorticoid induced changes
Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the...
ORGANISM(S): Homo sapiens 
2007-09-01 | E-GEOD-3040 | biostudies-arrayexpress
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