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GenomicsOSKM factors cooperatively engage chromatin to initiate reprogramming
Reprogramming cells from one fate to another, using transcription factors, generates cells for research and potential therapy, yet little is known about the initial engagement of reprogramming factors with the genome. We mapped the interactions between Oct4, Sox2, Klf4, and c-Myc (OSKM) and the hum...
ORGANISM(S): Homo sapiens 
2012-11-16 | E-GEOD-36570 | biostudies-arrayexpress
ProteomicsCell-type-specific functionality encoded within the intrinsically disordered regions of OCT4.
The cell-type-specific function of transcription factors (TFs) is crucial for determining several cellular identities. It is unclear how a single TF can function specifically in different cell types. Here, we define the molecular features that enable OCT4 to reprogram somatic cells into pluripotent ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD067538 | Pride
Oct4 Intrinsically disordered regions Embryonic stem (es) cells Transcription factors Slipers 
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