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TranscriptomicsGene expression in colon cancer stem cells (CSC) cultures identified by Wnt signaling levels
Primary colon CSC cultures were transduced with a Wnt responsive construct (TOP-GFP) and were single cell cloned. 10% highest and lowest TOP-GFP cell fractions were FACS sorted and arrayed. Primary colon CSC cultures with a responsive construct (TOP-GFP): high and low TOP-GFP cell fractions. 4 sampl...
ORGANISM(S): Homo sapiens 
2009-12-01 | E-GEOD-17375 | biostudies-arrayexpress
TranscriptomicsPeripheral tissue instruction is the primary determinant of CD8+ T cell pathogenicity: transcription profiling by array of donor CD8+ effector T cells isolated from the secondary lymphoid organs, blood and GVHD-target organs at D+6 post-transplant (F>M model)
This study reports the evolution of the donor CD8 effector T cell transcriptomes at multiple sites and time points within the same host following allo-SCT. Donor derived CD8+ T cells were flow sorted from multiple organs in mice developing GVHD in two clinically relevant murine models of H-2b MHC-ma...
ORGANISM(S): Mus musculus 
2018-03-28 | E-MTAB-5379 | biostudies-arrayexpress
TranscriptomicsPeripheral tissue instruction is the primary determinant of CD8+ T cell pathogenicity: transcription profiling by array of donor CD8+ effector T cells isolated from the secondary lymphoid organs, blood and GVHD-target organs at D+6 post-transplant (B6>129 model)
This study reports the evolution of the donor CD8 effector T cell transcriptomes at multiple sites and time points within the same host following allo-SCT. Donor derived CD8+ T cells were flow sorted from multiple organs in mice developing GVHD in two clinically relevant murine models of H-2b MHC-ma...
ORGANISM(S): Mus musculus 
2017-01-16 | E-MTAB-5378 | biostudies-arrayexpress
TranscriptomicsCharacterization of novel ovarian tumor cell lines that retain the phenotype of primary tumors [SNP]
The inability to establish stable cell lines from the vast majority of human tumors has limited the use of in vitro models to study human cancer. Currently available tumor cell lines fail to represent the biological diversity of human tumors. We have developed a cell culture medium that enabled us t...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-40787 | biostudies-arrayexpress
UnknownEarly High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients.
Not available
S-EPMC7306117 | biostudies-literature
TranscriptomicsOverexpression of Musashi1 (Msi1) in HEK293T cells.
Gene expression analysis of the Msi1 overexpression in HEK 293T cells. There were two biological replicates of Msi1 and GFP (Green Fluorescent Protein) as control, used in the experiment. Each slide includes 4 microarrays with one biological sample versus control. Samples were hybridized with dye-...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-13215 | biostudies-arrayexpress
TranscriptomicsDissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation
MLK3 gene mutations were described to occur in about 20% of microsatellite unstable gastrointestinal cancers and to harbor oncogenic activity. In particular, mutation P252H, located in the kinase domain, was found to have a strong transforming potential, and to promote the growth of highly invasive ...
ORGANISM(S): Homo sapiens 
2014-03-21 | E-GEOD-54611 | biostudies-arrayexpress
TranscriptomicsGene expression in CF-vs-non CF human airway epithelial cell samples obtained by nasal brushing.
A small-scale whole genome microarray study of gene expression in human native nasal epithelial cells from F508del-CFTR homozygous CF patients and non-CF controls. We used the custom designed Affymetrix HsAirwaya520108F Arrays to compare gene expression in 5 CF and 5 non CF nasal epithelial cell sam...
ORGANISM(S): Homo sapiens 
2013-04-10 | E-GEOD-40445 | biostudies-arrayexpress
TranscriptomicsIn vivo transcriptome of Listeria monocytogenes EGDe
Time course study of the mouse infection by comparing the genomic transcriptional patterns of Listeria monocytogenes EGDe grown under laboratory conditions (exponential growth phase) with that of in vivo-grown bacteria (in mouse spleens) over three days of infection. Time course study of the mouse i...
ORGANISM(S): Listeria monocytogenes EGD-e 
2010-06-25 | E-GEOD-13057 | biostudies-arrayexpress
TranscriptomicsLack of microRNA-101 causes E-cadherin expression and function deregulation through EZH2 up-regulation in gastric cancer
Background & Aims: E-cadherin expression disruption is commonly observed in epithelial cancers and metastasis. Such event is also recognized as a crucial step in gastric cancer (GC) initiation and progression. As aberrant expression of microRNAs often perturb the normal expression and function of pi...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-33743 | biostudies-arrayexpress
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